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Escartin, C.* ; Galea, E.* ; Lakatos, A.* ; O'Callaghan, J.P.* ; Petzold, G.C.* ; Serrano-Pozo, A.* ; Steinhäuser, C.* ; Volterra, A.* ; Carmignoto, G.* ; Agarwal, A.* ; Allen, N.J.* ; Araque, A.* ; Barbeito, L.* ; Barzilai, A.* ; Bergles, D.E.* ; Bonvento, G.* ; Butt, A.M.* ; Chen, W.T.* ; Cohen-Salmon, M.* ; Cunningham, C.* ; Deneen, B.* ; de Strooper, B.* ; Díaz-Castro, B.* ; Farina, C.* ; Freeman, M.* ; Gallo, V.* ; Goldman, J.E.* ; Goldman, S.A.* ; Götz, M. ; Gutiérrez, A.* ; Haydon, P.G.* ; Heiland, D.H.* ; Hol, E.M.* ; Holt, M.G.* ; Iino, M.* ; Kastanenka, K.V.* ; Kettenmann, H.* ; Khakh, B.S.* ; Koizumi, S.* ; Lee, C.J.* ; Liddelow, S.A.* ; MacVicar, B.A.* ; Magistretti, P.* ; Messing, A.* ; Mishra, A.* ; Molofsky, A.V.* ; Murai, K.K.* ; Norris, C.M.* ; Okada, S.* ; Oliet, S.H.R.* ; Oliveira, J.F.* ; Panatier, A.* ; Parpura, V.* ; Pekna, M.* ; Pekny, M.* ; Pellerin, L.* ; Perea, G.* ; Pérez-Nievas, B.G.* ; Pfrieger, F.W.* ; Poskanzer, K.E.* ; Quintana, F.J.* ; Ransohoff, R.M.* ; Riquelme-Perez, M.* ; Robel, S.* ; Rose, C.R.* ; Rothstein, J.D.* ; Rouach, N.* ; Rowitch, D.H.* ; Semyanov, A.* ; Sirko, S. ; Sontheimer, H.* ; Swanson, R.A.* ; Vitorica, J.* ; Wanner, I.B.* ; Wood, L.B.* ; Wu, J.* ; Zheng, B.* ; Zimmer, E.R.* ; Zorec, R.* ; Sofroniew, M.V.* ; Verkhratsky, A.*

Reactive astrocyte nomenclature, definitions, and future directions.

Nat. Neurosci. 24, 312-325 (2021)
Postprint DOI PMC
Open Access Green
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Zeitschrift Nature Neuroscience
Quellenangaben Band: 24, Heft: 3, Seiten: 312-325 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
Förderungen Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
NIMH NIH HHS
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
Alzheimer's Association
Deutsche Forschungsgemeinschaft (German Research Foundation)
NIA NIH HHS