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Gerling, K.* ; Herrmann, L.M.* ; Salewski, C.* ; Wolf, M.* ; Müllerbader, P.* ; Siegel-Axel, D. ; Wendel, H.P.* ; Schlensak, C.* ; Avci-Adali, M.* ; Stoppelkamp, S.*

Synthetic material abdominal swabs reduce activation of platelets and leukocytes compared to cotton materials.

Biomolecules 11:1023 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
During surgical procedures, cotton abdominal swabs with their high absorptive capacity and malleability are used to retain organs and absorb blood or other body fluids. Such properties of the natural material cotton are advantageous for most operations, but in cardiopulmonary bypass (CPB) surgery, a high blood volume can accumulate in the thoracic cavity that is quickly retransfused via the heart–lung machine (HLM). This common practice is supposed to be safe due to the high anticoagulation. However, in vitro analyses showed that blood cells and plasma proteins were activated despite a high anticoagulation, which can propagate especially an inflammatory response in the patient. Thus, we investigated patients’ blood during CPB surgery for inflammatory and coagulation-associated activation after contact to the HLM and either cotton or synthetic abdominal swabs. Contact with cotton significantly increased thrombocyte and neutrophil activation measured as β-thromboglobulin and PMN-elastase secretion, respectively, compared to synthetic abdominal swabs. Both inflammatory cytokines, interleukin (IL) 1β and IL6, were also significantly increased in the cotton over the synthetic patient group, while SDF-1α was significantly lower in the synthetic group. Our data show for the first time that cotton materials can activate platelets and leukocytes despite a high anticoagulation and that this activation is lower with synthetic materials. This additional activation due to the material on top of the activation exerted by the tissue contact that blood is exposed to during CPB surgery can propagate further reactions in patients after surgery, which poses a risk for this already vulnerable patient group.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Abdominal Swabs ; Cardiopulmonary Bypass Surgery ; Cotton ; Heart–lung Machine ; Systemic Inflammation; Molecular-weight Heparin; Cardiopulmonary Bypass; Progenitor Cells; Cardiac-surgery; On-pump; Blood; Il-1-beta; Neutrophils; Expression; Mechanism
ISSN (print) / ISBN 2218-273X
e-ISSN 2218-273X
Zeitschrift Biomolecules
Quellenangaben Band: 11, Heft: 7, Seiten: , Artikelnummer: 1023 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Open Access Publishing Fund of University of Tubingen