PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
So, R.* ; Chen, J.* ; Mehta, A.J.* ; Liu, S.* ; Strak, M.* ; Wolf, K. ; Hvidtfeldt, U.A.* ; Rodopoulou, S.* ; Stafoggia, M.* ; Klompmaker, J.O.* ; Samoli, E.* ; Raaschou-Nielsen, O.* ; Atkinson, R.* ; Bauwelinck, M.* ; Bellander, T.* ; Boutron-Ruault, M.C.* ; Brandt, J.* ; Brunekreef, B.* ; Cesaroni, G.* ; Concin, H.* ; Forastiere, F.* ; van Gils, C.H.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.* ; de Hoogh, K.* ; Janssen, N.* ; Lim, Y.H.* ; Westendorp, R.G.* ; Jørgensen, J.T.* ; Katsouyanni, K.* ; Ketzel, M.* ; Lager, A.* ; Lang, A.* ; Ljungman, P.L.S.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Simonsen, M.K.* ; Pershagen, G.* ; Peter, R.S.* ; Peters, A. ; Renzi, M.* ; Rizzuto, D.* ; Sigsgaard, T.* ; Vienneau, D.* ; Weinmayr, G.* ; Severi, G.* ; Fecht, D.* ; Tjønneland, A.* ; Leander, K.* ; Hoek, G.* ; Andersen, Z.J.*

Long-term exposure to air pollution and liver cancer incidence in six European cohorts.

Int. J. Cancer 149, 1887–1897 (2021)
Verlagsversion Postprint Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Particulate matter air pollution and diesel engine exhaust have been classified as carcinogenic for lung cancer, yet few studies have explored associations with liver cancer. We used six European adult cohorts which were recruited between 1985 and 2005, pooled within the 'Effects of low-level air pollution: A study in Europe' (ELAPSE) project, and followed for the incidence of liver cancer until 2011 to 2015. The annual average exposure to nitrogen dioxide (NO2 ), particulate matter with diameter < 2.5 μm (PM2.5 ), black carbon (BC), warm-season ozone (O3 ), and eight elemental components of PM2.5 (copper, iron, zinc, sulfur, nickel, vanadium, silicon, potassium) were estimated by European-wide hybrid land-use regression models at participants' residential addresses. We analyzed the association between air pollution and liver cancer incidence by Cox proportional hazards models adjusting for potential confounders. Of 330,064 cancer-free adults at baseline, 512 developed liver cancer during a mean follow-up of 18.1 years. We observed positive linear associations between NO2 (hazard ratio, 95% confidence interval: 1.17, 1.02-1.35 per 10 μg/m3 ), PM2.5 (1.12, 0.92-1.36 per 5 μg/m3 ), and BC (1.15, 1.00-1.33 per 0.5 10-5 /m) and liver cancer incidence. Associations with NO2 and BC persisted in two-pollutant models with PM2.5 . Most components of PM2.5 were associated with the risk of liver cancer, with the strongest associations for sulfur and vanadium, which were robust to adjustment for PM2.5 or NO2 . Our study suggests that ambient air pollution may increase the risk of liver cancer, even at concentrations below current EU standards. This article is protected by copyright. All rights reserved.
Impact Factor
Scopus SNIP
Scopus
Cited By
Altmetric
7.396
0.000
2
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Liver Cancer Incidence ; Particulate Matter; Cohort Study; Use Regression-models; Hepatocellular-carcinoma; Men; Profile; Pm2.5; Risk; Lung; Participation; Population; Prevalence
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Zeitschrift International Journal of Cancer
Quellenangaben Band: 149, Heft: , Seiten: 1887–1897 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-001
G-504000-010
Förderungen United States Environmental Protection Agency (EPA)
Novo Nordisk Foundation Challenge Programme
Health Effects Institute Research Agreement
DOI 10.1002/ijc.33743
WOS ID WOS:000684831700001
Scopus ID 85112352135
PubMed ID 34278567
Erfassungsdatum 2021-08-03
[➜Korrektur melden]