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Sciascia, Q.L.* ; Prehn, C. ; Adamski, J. ; Daş, G.* ; Lang, I.S.* ; Otten, W.* ; Görs, S.* ; Metges, C.C.*

The effect of dietary protein imbalance during pregnancy on the growth, metabolism and circulatory metabolome of neonatal and weaned juvenile porcine offspring.

Nutrients 13:3286 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Protein imbalance during pregnancy affects women in underdeveloped and developing countries and is associated with compromised offspring growth and an increased risk of metabolic diseases in later life. We studied in a porcine model the glucose and urea metabolism, and circulatory hormone and metabolite profile of offspring exposed during gestation, to maternal isoenergetic low–high (LP-HC), high–low (HP-LC) or adequate (AP) protein–carbohydrate ratio diets. At birth, LP-HC were lighter and the plasma acetylcarnitine to free carnitine ratios at 1 day of life was lower compared to AP offspring. Plasma urea concentrations were lower in 1 day old LP-HC offspring than HP-LC. In the juvenile period, increased insulin concentrations were observed in LP-HC and HP-LC offspring compared to AP, as was body weight from HP-LC compared to LP-HC. Plasma triglyceride concentrations were lower in 80 than 1 day old HP-LC offspring, and glucagon concentrations lower in 80 than 1 day old AP and HP-LC offspring. Plasma urea and the ratio of glucagon to insulin were lower in all 80 than 1 day old offspring. Aminoacyl-tRNA, arginine and phenylala-nine, tyrosine and tryptophan metabolism, histidine and beta-alanine metabolism differed between 1 and 80 day old AP and HP-LC offspring. Maternal protein imbalance throughout pregnancy did not result in significant consequences in offspring metabolism compared to AP, indicating enor-mous plasticity by the placenta and developing offspring.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Body Weight ; Carbohydrate And Urea Metabolism ; Maternal Protein Restriction ; Metabolomics ; Offspring ; Porcine Model; Prenatal Exposure; Skeletal-muscle; Gene-expression; Adipose-tissue; Animal-models; Maternal Low; Cell-cycle; Gestation; Plasma; Pig
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Zeitschrift Nutrients
Quellenangaben Band: 13, Heft: 9, Seiten: , Artikelnummer: 3286 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)
Förderungen Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft