PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Loeffelholz, C.V.* ; Roth, J.* ; Coldewey, S.M.* ; Birkenfeld, A.L.

The role of physical activity in nonalcoholic and metabolic dysfunction associated fatty liver disease.

Biomedicines 9:1853 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and particularly with nonalcoholic/metabolic dysfunction associated fatty liver disease (NAFLD/MAFLD). Insulin resistance (IR) represents an early pathophysiologic key element of NAFLD/MAFLD, prediabetes and T2D. Current treatment guidelines recommend regular physical activity. There is evidence, that physical exercise has impact on a variety of molecular pathways, such as AMP-activated protein kinase and insulin signaling as well as glucose transporter 4 translocation, modulating insulin action, cellular substrate flow and in particular ectopic lipid and glycogen storage in a positive manner. Therefore, physical exercise can lead to substantial clinical benefit in persons with diabetes and/or NAFLD/MAFLD. However, experience from long term observational studies shows that the patients' motivation to exercise regularly appears to be a major limitation. Strategies to integrate everyday physical activity (i.e., nonexercise activity thermogenesis) in lifestyle treatment schedules might be a promising approach. This review aggregates evidence on the impact of regular physical activity on selected molecular mechanisms as well as clinical outcomes of patients suffering from IR and NAFLD/MAFLD.
Impact Factor
Scopus SNIP
Scopus
Cited By
Altmetric
6.081
1.444
3
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Amp Activated Protein Kinase ; Ectopic Lipids ; Insulin Resistance ; Nonexercise Activity Thermogenesis ; Type 2 Diabetes; Life-style Intervention; Impaired Glucose-tolerance; Short-term Exercise; Protein-kinase-c; Insulin-resistance; Hepatocellular-carcinoma; Mitochondrial-function; Diabetes Prevention; Phosphatidic-acid; Fibrosis Stage
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2227-9059
e-ISSN 2227-9059
Zeitschrift Biomedicines
Quellenangaben Band: 9, Heft: 12, Seiten: , Artikelnummer: 1853 Supplement: ,
Verlag MDPI
Verlagsort Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen Federal Ministry of Education and Research within the Centre for Innovation Competence Septomics
DFG
DOI 10.3390/biomedicines9121853
WOS ID WOS:000735982100001
Scopus ID 85121713474
PubMed ID 34944668
Erfassungsdatum 2022-02-02
[➜Korrektur melden]