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Loeffelholz, C.V.* ; Roth, J.* ; Coldewey, S.M.* ; Birkenfeld, A.L.

The role of physical activity in nonalcoholic and metabolic dysfunction associated fatty liver disease.

Biomedicines 9:1853 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and particularly with nonalcoholic/metabolic dysfunction associated fatty liver disease (NAFLD/MAFLD). Insulin resistance (IR) represents an early pathophysiologic key element of NAFLD/MAFLD, prediabetes and T2D. Current treatment guidelines recommend regular physical activity. There is evidence, that physical exercise has impact on a variety of molecular pathways, such as AMP-activated protein kinase and insulin signaling as well as glucose transporter 4 translocation, modulating insulin action, cellular substrate flow and in particular ectopic lipid and glycogen storage in a positive manner. Therefore, physical exercise can lead to substantial clinical benefit in persons with diabetes and/or NAFLD/MAFLD. However, experience from long term observational studies shows that the patients' motivation to exercise regularly appears to be a major limitation. Strategies to integrate everyday physical activity (i.e., nonexercise activity thermogenesis) in lifestyle treatment schedules might be a promising approach. This review aggregates evidence on the impact of regular physical activity on selected molecular mechanisms as well as clinical outcomes of patients suffering from IR and NAFLD/MAFLD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Amp Activated Protein Kinase ; Ectopic Lipids ; Insulin Resistance ; Nonexercise Activity Thermogenesis ; Type 2 Diabetes; Life-style Intervention; Impaired Glucose-tolerance; Short-term Exercise; Protein-kinase-c; Insulin-resistance; Hepatocellular-carcinoma; Mitochondrial-function; Diabetes Prevention; Phosphatidic-acid; Fibrosis Stage
ISSN (print) / ISBN 2227-9059
e-ISSN 2227-9059
Zeitschrift Biomedicines
Quellenangaben Band: 9, Heft: 12, Seiten: , Artikelnummer: 1853 Supplement: ,
Verlag MDPI
Verlagsort Basel, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Federal Ministry of Education and Research within the Centre for Innovation Competence Septomics
DFG