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Schult, D.* ; Reitmeier, S.* ; Koyumdzhieva, P.* ; Lahmer, T.* ; Middelhof, M.* ; Erber, J.* ; Schneider, J.* ; Kager, J.* ; Frolova, M.* ; Horstmann, J.* ; Fricke, L.* ; Steiger, K.* ; Jesinghaus, M.* ; Janssen, K.P.* ; Protzer, U. ; Neuhaus, K.* ; Schmid, R.M.* ; Haller, D.* ; Quante, M.*

Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19.

Gut Microbes 14:2031840 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
There is a growing debate about the involvement of the gut microbiome in COVID-19, although it is not conclusively understood whether the microbiome has an impact on COVID-19, or vice versa, especially as analysis of amplicon data in hospitalized patients requires sophisticated cohort recruitment and integration of clinical parameters. Here, we analyzed fecal and saliva samples from SARS-CoV-2 infected and post COVID-19 patients and controls considering multiple influencing factors during hospitalization. 16S rRNA gene sequencing was performed on fecal and saliva samples from 108 COVID-19 and 22 post COVID-19 patients, 20 pneumonia controls and 26 asymptomatic controls. Patients were recruited over the first and second corona wave in Germany and detailed clinical parameters were considered. Serial samples per individual allowed intra-individual analysis. We found the gut and oral microbiota to be altered depending on number and type of COVID-19-associated complications and disease severity. The occurrence of individual complications was correlated with low-risk (e.g., Faecalibacterium prausznitzii) and high-risk bacteria (e.g., Parabacteroides ssp.). We demonstrated that a stable gut bacterial composition was associated with a favorable disease progression. Based on gut microbial profiles, we identified a model to estimate mortality in COVID-19. Gut microbiota are associated with the occurrence of complications in COVID-19 and may thereby influencing disease severity. A stable gut microbial composition may contribute to a favorable disease progression and using bacterial signatures to estimate mortality could contribute to diagnostic approaches. Importantly, we highlight challenges in the analysis of microbial data in the context of hospitalization.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Coronavirus ; Sars-cov-2 ; Complications ; Gut Microbiome ; Oral Microbiome; Microbiome
ISSN (print) / ISBN 1949-0976
e-ISSN 1949-0984
Zeitschrift Gut Microbes
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 2031840 Supplement: ,
Verlag Landes Bioscience
Verlagsort 530 Walnut Street, Ste 850, Philadelphia, Pa 19106 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
Förderungen Technical University of Munich
Deutsche Forschungsgemeinschaft (DFG)