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Huber, R. ; Braselmann, H. ; Geinitz, H.* ; Jaehnert, I. ; Baumgartner, A. ; Thamm, R.* ; Figel, M. ; Molls, M.* ; Zitzelsberger, H.

Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study.

Radiat. Oncol. 6:32 (2011)
Verlagsversion Volltext DOI PMC
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Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. METHODS: Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. RESULTS: Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. CONCLUSIONS: The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Breast-cancer patients; Peripheral-blood lyphocytes; Normal tissue-damage; Biological dosimetry; Individual radiosensitivity; Genetic predisposition; Dicentric frequencies; Ionizing-radiation; Absorbed radiation; Neck-cancer
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 1748-717X
e-ISSN 1748-717X
Zeitschrift Radiation Oncology
Quellenangaben Band: 6, Heft: 1, Seiten: , Artikelnummer: 32 Supplement: ,
Verlag BioMed Central
Begutachtungsstatus Peer reviewed
Institut(e) Translational Metabolic Oncology (IDC-TMO)
Auswertungsstelle (AWST)
POF Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501000-001
A-660200-001
PubMed ID 21473753
DOI 10.1186/1748-717X-6-32
Scopus ID 79953687976
Erfassungsdatum 2011-08-10
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