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Raineri, S.* ; Sherriff, J.A.* ; Thompson, K.S.J.* ; Jones, H.* ; Pfluger, P.T. ; Ilott, N.E.* ; Mellor, J.*

Pharmacologically induced weight loss is associated with distinct gut microbiome changes in obese rats.

BMC Microbiol. 22:91 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Obesity, metabolic disease and some psychiatric conditions are associated with changes to relative abundance of bacterial species and specific genes in the faecal microbiome. Little is known about the impact of pharmacologically induced weight loss on distinct microbiome species and their respective gene programs in obese individuals. METHODOLOGY: Using shotgun metagenomics, the composition of the microbiome was obtained for two cohorts of obese female Wistar rats (n = 10-12, total of 82) maintained on a high fat diet before and after a 42-day treatment with a panel of four investigatory or approved anti-obesity drugs (tacrolimus/FK506, bupropion, naltrexone and sibutramine), alone or in combination. RESULTS: Only sibutramine treatment induced consistent weight loss and improved glycaemic control in the obese rats. Weight loss was associated with reduced food intake and changes to the faecal microbiome in multiple microbial taxa, genes, and pathways. These include increased β-diversity, increased relative abundance of multiple Bacteroides species, increased Bacteroides/Firmicutes ratio and changes to abundance of genes and species associated with obesity-induced inflammation, particularly those encoding components of the flagellum and its assembly. CONCLUSIONS: Sibutramine-induced weight loss in obese rats is associated with improved metabolic health, and changes to the faecal microbiome consistent with a reduction in obesity-induced bacterially-driven inflammation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Bupropion ; Faecal Microbiome ; Naltrexone ; Obese Female Wistar Rats ; Obesity ; Shotgun Metagenomics ; Sibutramine ; Tacrolimus/fk506 ; Weight Loss ; Weight Loss Drugs
e-ISSN 1471-2180
Zeitschrift BMC Microbiology
Quellenangaben Band: 22, Heft: 1, Seiten: , Artikelnummer: 91 Supplement: ,
Verlag BioMed Central
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Förderungen Biotechnology and Biological Sciences Research Council
H2020 Marie Skłodowska-Curie Actions