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Badpa, M. ; Wolf, K. ; Schneider, A.E. ; Winkler, C. ; Haupt, F. ; Peters, A. ; Ziegler, A.-G.

Association of long-term environmental exposures in pregnancy and early life with islet autoimmunity development in children in Bavaria, Germany.

Environ. Res. 212:113503 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
OBJECTIVE: Incidence of early-onset type 1 diabetes (T1D) has been increasing worldwide. Only few studies examined the relationship between geographical environmental variation and T1D incidence or its presymptomatic stage of islet autoimmunity. Our study aimed to investigate the effect of long-term environmental exposures during pregnancy and early life on childhood islet autoimmunity. RESEARCH DESIGN AND METHODS: We used data from the Fr1da cohort study which screened children aged 1.75-5.99 years for multiple islet autoantibodies in Bavaria, Germany between 2015 and 2019. We included 85,251 children with valid residential information. Daily averages for particulate matter with a diameter <2.5 μm, nitrogen dioxide, ozone, air temperature, and greenness were averaged for each zip-code or directly assigned to the addresses. The exposure windows included pregnancy, the first year and the first two years of life. Generalized additive models adjusting for individual and socioeconomic variables were used to investigate associations between environmental exposures and islet autoimmunity development. RESULTS: Islet autoimmunity was diagnosed in 272 children. Colder air temperature during pregnancy was associated with developing islet autoimmunity at the address (per 2.2 °C decrease, Odds ratio (OR): 1.49; 95% Confidence interval (CI): 1.21-1.83) and zip-code level (per 2.4 °C decrease, OR: 1.31; 95% CI: 1.08-1.59). Using the addresses, significant associations were also observed during the first years of life. CONCLUSION: In this study, children's residential exposure to lower levels of air temperature during pregnancy and early life increased the risk of islet autoimmunity before the age of six.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Air Temperature ; Greenness ; Islet Autoimmunity ; Long-term Exposure ; Socioeconomic Factors
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0013-9351
e-ISSN 1096-0953
Zeitschrift Environmental Research
Quellenangaben Band: 212, Heft: , Seiten: , Artikelnummer: 113503 Supplement: ,
Verlag Elsevier
Verlagsort San Diego, Calif.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
Institute of Epidemiology (EPI)
POF Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP-Element(e) G-502100-001
G-504000-010
G-504000-001
G-501900-217
G-501900-211
Förderungen Bundesministerium für Bildung und Forschung
Leona M. and Harry B. Helmsley Charitable Trust
Juvenile Diabetes Research Foundation International
LifeScience-Stiftung
HMGU
Bavarian State Ministry of Health and Care
Bavarian State Ministry of Health
Bavaria Germany and Care
DOI 10.1016/j.envres.2022.113503
WOS ID WOS:000812319000010
Scopus ID 85131125698
PubMed ID 35609657
Erfassungsdatum 2022-07-04
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