PuSH - Publikationsserver des Helmholtz Zentrums München: Repeat-based holocentromeres influence genome architecture and karyotype evolution.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Hofstatter, P.G.* ; Thangavel, G.* ; Lux, T. ; Neumann, P.* ; Vondrak, T.* ; Novak, P.* ; Zhang, M.* ; Costa, L.T.* ; Castellani, M.* ; Scott, A.* ; Toegelová, H.* ; Fuchs, J.* ; Mata-Sucre, Y.* ; Dias, Y.* ; Vanzela, A.L.L.* ; Huettel, B.* ; Almeida, C.C.S.* ; Šimková, H.* ; Souza, G.* ; Pedrosa-Harand, A.* ; Macas, J.* ; Mayer, K.F.X. ; Houben, A.* ; Marques, A.R.*

Repeat-based holocentromeres influence genome architecture and karyotype evolution.

Cell 185, 3153-3168.e18 (2022)

Verlagsversion

Forschungsdaten

DOI

PMC

	Open Access Hybrid

Abstract
Metriken
Zusatzinfos

The centromere represents a single region in most eukaryotic chromosomes. However, several plant and animal lineages assemble holocentromeres along the entire chromosome length. Here, we compare genome organization and evolution as a function of centromere type by assembling chromosome-scale holocentric genomes with repeat-based holocentromeres from three beak-sedge (Rhynchospora pubera, R. breviuscula, and R. tenuis) and their closest monocentric relative, Juncus effusus. We demonstrate that transition to holocentricity affected 3D genome architecture by redefining genomic compartments, while distributing centromere function to thousands of repeat-based centromere units genome-wide. We uncover a complex genome organization in R. pubera that hides its unexpected octoploidy and describe a marked reduction in chromosome number for R. tenuis, which has only two chromosomes. We show that chromosome fusions, facilitated by repeat-based holocentromeres, promoted karyotype evolution and diploidization. Our study thus sheds light on several important aspects of genome architecture and evolution influenced by centromere organization.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

66.850

9.437