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Kilanowski, A. ; Thiering, E. ; Wang, G.* ; Kumar, A.* ; Kress, S.* ; Flexeder, C. ; Bauer, C.P.* ; Berdel, D.* ; von Berg, A.* ; Bergström, A.* ; Gappa, M.* ; Heinrich, J.* ; Herberth, G.* ; Koletzko, S.* ; Kull, I.* ; Melén, E.* ; Schikowski, T.* ; Peters, A. ; Standl, M.

Allergic disease trajectories up to adolescence: Characteristics, early-life and genetic determinants.

Allergy 78, 836-850 (2023)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
BACKGROUND: Allergic diseases often develop jointly during early childhood but differ in timing of onset, remission and progression. Their disease course over time is often difficult to predict and determinants are not well understood. OBJECTIVES: We aimed to identify trajectories of allergic diseases up to adolescence and to investigate their association with early-life and genetic determinants and clinical characteristics. METHODS: Longitudinal k-means clustering was used to derive trajectories of allergic diseases (asthma, atopic dermatitis and rhinitis) in two German birth cohorts (GINIplus/LISA). Associations with early-life determinants, polygenic risk scores, food and aeroallergen sensitization and lung function were estimated by multinomial models. Results were replicated in the independent Swedish BAMSE cohort. RESULTS: Seven allergic disease trajectories were identified: "Intermittently allergic", "rhinitis", "early-resolving dermatitis", "mid-persisting dermatitis", "multimorbid", "persisting dermatitis plus rhinitis" and "early-transient asthma". Family history of allergies was more prevalent in all allergic disease trajectories compared the non-allergic controls with stronger effect sizes for clusters comprising more than one allergic disease (e.g. RRR=5.0, 95%CI=[3.1-8.0] in the multimorbid versus 1.8[1.4-2.4] in the mild intermittently allergic cluster). Specific polygenic risk scores for single allergic diseases were significantly associated with their relevant trajectories. The derived trajectories and their association with genetic effects and clinical characteristics showed similar results in BAMSE. CONCLUSION: Seven robust allergic clusters were identified and showed associations with early life and genetic factors as well as clinical characteristics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Allergic Diseases ; Epidemiology ; Longitudinal Clustering ; Polygenic Risk Score ; Trajectories; Atopic-dermatitis; Hay-fever; Asthma; Eczema; Childhood; Birth; Rhinitis; Risk; Persistence; Multimorbidity
Sprache englisch
Veröffentlichungsjahr 2023
Prepublished im Jahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 78, Heft: 3, Seiten: 836-850 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-008
G-504000-009
G-504000-010
Förderungen Commission of the European Communities, the 7th Framework Program
Federal Ministry for Environment (IUF Dusseldorf)
Fondation Nestle
H2020 European Research Council
Helmholtz Zentrum Munchen
Helmholtz-Zentrum fur Umweltforschung
Hjart-Lungfonden
Bundesministerium für Bildung und Forschung
Region Stockholm
Leibniz Research-Institute for Environmental Medicine at the University of Dusseldorf
Ludwig-Maximilians-Universitat Munchen
Marien-Hospital Wesel
Mead Johnson Nutrition
Pediatric Practice, Bad Honnef
Swedish Research Council
Technische Universitat Munchen
Karolinska Institutet SFO Epidemiology
DOI 10.1111/all.15511
WOS ID 000857034000001
WOS ID WOS:000857034000001
Scopus ID 85138252961
PubMed ID 36069615
Erfassungsdatum 2022-11-21
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