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Hvidtfeldt, U.A.* ; Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.H.* ; Katsouyanni, K.* ; Ketzel, M.* ; Brynedal, B.* ; Leander, K.* ; Ljungman, P.L.S.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Rizzuto, D.* ; Boutron-Ruault, M.C.* ; Samoli, E.* ; So, R.* ; Stafoggia, M.* ; Tjønneland, A.* ; Vermeulen, R.* ; Verschuren, W.M.M.* ; Weinmayr, G.* ; Wolf, K. ; Zhang, J.* ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.*

Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort.

Cancer Epidemiol. Biomarkers Prev. 32, 105-113 (2023)
Verlagsversion Postprint DOI PMC
Open Access Green
BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n=199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.03 (1.00, 1.06) per 10 μg/m³ NO2, 1.06 (1.01, 1.11) per 5 μg/m³ PM2.5, 1.03 (0.99, 1.06) per 0.5 10-5m-1 BC, and 0.98 (0.94, 1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5 and BC in development of breast cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter ELAPSE, Gesundheitseffekte von Luftschadstoffen; Risk-factors; Population; Health; Men; Profile; Pm2.5; Dioxide; Models; Women; Life
ISSN (print) / ISBN 1055-9965
e-ISSN 1538-7755
Zeitschrift Cancer Epidemiology, Biomarkers & Prevention
Quellenangaben Band: 32, Heft: 1, Seiten: 105-113 Artikelnummer: , Supplement: ,
Verlag American Association for Cancer Research (AACR)
Verlagsort 615 Chestnut St, 17th Floor, Philadelphia, Pa 19106-4404 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen
United States Environmental Protection Agency (EPA)