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Jiang, D. ; Guo, R. ; Machens, H.G.* ; Rinkevich, Y.

Diversity of fibroblasts and their roles in wound healing.

Cold Spring Harbor Perspect. Biol. 15:a041222 (2023)
DOI PMC
Wound healing disorders are a societal, clinical, and healthcare burden and understanding and treating them is a major challenge. A particularly important cell type in the wound healing processes is the fibroblast. Fibroblasts are not homogenous; however, there are diverse functional fibroblast subtypes coming from different embryonic origins and residing in dispersed anatomic locations including distinct classes of fibroblasts at various skin depths. In this review, we discuss the implications of fibroblast heterogeneity, with a focus on the fundamental physiological functions of the fibroblast subtypes that govern wound repair and clinical degrees of healing. A better understanding of these diverse functional fibroblast populations will likely lead to novel therapies to enhance wound healing and inhibit excessive scarring.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Granulation-tissue; Regeneration; Skin; Myofibroblasts; Contraction; Compendium; Mechanism; Burden
Sprache englisch
Veröffentlichungsjahr 2023
Prepublished im Jahr 2022
HGF-Berichtsjahr 2022
e-ISSN 1943-0264
Zeitschrift Cold Spring Harbor Perspectives in Biology
Quellenangaben Band: 15, Heft: 3, Seiten: , Artikelnummer: a041222 Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Verlagsort 1 Bungtown Rd, Cold Spring Harbor, Ny 11724 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
Förderungen European Foundation for the Study of Diabetes (EFSD)
LEO Foundation
European Research Council
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award
DOI 10.1101/cshperspect.a041222
WOS ID 000942734300001
Scopus ID 85149168498
PubMed ID 36167647
Erfassungsdatum 2022-10-20
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