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Jiang, D. ; Guo, R. ; Machens, H.G.* ; Rinkevich, Y.

Diversity of fibroblasts and their roles in wound healing.

Cold Spring Harbor Perspect. Biol. 15:a041222 (2023)
DOI PMC
Wound healing disorders are a societal, clinical, and healthcare burden and understanding and treating them is a major challenge. A particularly important cell type in the wound healing processes is the fibroblast. Fibroblasts are not homogenous; however, there are diverse functional fibroblast subtypes coming from different embryonic origins and residing in dispersed anatomic locations including distinct classes of fibroblasts at various skin depths. In this review, we discuss the implications of fibroblast heterogeneity, with a focus on the fundamental physiological functions of the fibroblast subtypes that govern wound repair and clinical degrees of healing. A better understanding of these diverse functional fibroblast populations will likely lead to novel therapies to enhance wound healing and inhibit excessive scarring.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Granulation-tissue; Regeneration; Skin; Myofibroblasts; Contraction; Compendium; Mechanism; Burden
e-ISSN 1943-0264
Zeitschrift Cold Spring Harbor Perspectives in Biology
Quellenangaben Band: 15, Heft: 3, Seiten: , Artikelnummer: a041222 Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Verlagsort 1 Bungtown Rd, Cold Spring Harbor, Ny 11724 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology (IRBM)
Förderungen European Foundation for the Study of Diabetes (EFSD)
LEO Foundation
European Research Council
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award