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Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts.
BMC Med. 21:80 (2023)
BACKGROUND: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. METHODS: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. RESULTS: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87-0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75-0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89-1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. CONCLUSIONS: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
9.300
0.000
2
Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Amino Acids ; Colorectal Cancer ; Glutamine ; Histidine; Histamine; Metaanalysis; Metabolism
Sprache
englisch
Veröffentlichungsjahr
2023
HGF-Berichtsjahr
2023
ISSN (print) / ISBN
1741-7015
e-ISSN
1741-7015
Zeitschrift
BMC Medicine
Quellenangaben
Band: 21,
Heft: 1,
Artikelnummer: 80
Verlag
BioMed Central
Verlagsort
Campus, 4 Crinan St, London N1 9xw, England
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30505 - New Technologies for Biomedical Discoveries
30201 - Metabolic Health
30201 - Metabolic Health
Forschungsfeld(er)
Enabling and Novel Technologies
Genetics and Epidemiology
Genetics and Epidemiology
PSP-Element(e)
A-630710-001
G-500600-001
G-500600-001
WOS ID
000940903600001
Scopus ID
85149153333
PubMed ID
36855092
Erfassungsdatum
2023-03-08