PuSH - Publikationsserver des Helmholtz Zentrums München

Noltes, M.E.* ; Bader, M. ; Metman, M.J.H.* ; Vonk, J.* ; Steinkamp, P.J.* ; Kukacka, J. ; Westerlaan, H.E.* ; Dierckx, R.A.J.O.* ; van Hemel, B.M.* ; Brouwers, A.H.* ; van Dam, G.M.* ; Jüstel, D. ; Ntziachristos, V. ; Kruijff, S.*

Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography.

Eur. J. Nucl. Med. Mol. Imaging 50, 2736-2750 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
PURPOSE: Patient-tailored management of thyroid nodules requires improved risk of malignancy stratification by accurate preoperative nodule assessment, aiming to personalize decisions concerning diagnostics and treatment. Here, we perform an exploratory pilot study to identify possible patterns on multispectral optoacoustic tomography (MSOT) for thyroid malignancy stratification. For the first time, we directly correlate MSOT images with histopathology data on a detailed level. METHODS: We use recently enhanced data processing and image reconstruction methods for MSOT to provide next-level image quality by means of improved spatial resolution and spectral contrast. We examine optoacoustic features in thyroid nodules associated with vascular patterns and correlate these directly with reference histopathology. RESULTS: Our methods show the ability to resolve blood vessels with diameters of 250 μm at depths of up to 2 cm. The vessel diameters derived on MSOT showed an excellent correlation (R2-score of 0.9426) with the vessel diameters on histopathology. Subsequently, we identify features of malignancy observable in MSOT, such as intranodular microvascularity and extrathyroidal extension verified by histopathology. Despite these promising features in selected patients, we could not determine statistically relevant differences between benign and malignant thyroid nodules based on mean oxygen saturation in thyroid nodules. Thus, we illustrate general imaging artifacts of the whole field of optoacoustic imaging that reduce image fidelity and distort spectral contrast, which impedes quantification of chromophore presence based on mean concentrations. CONCLUSION: We recommend examining optoacoustic features in addition to chromophore quantification to rank malignancy risk. We present optoacoustic images of thyroid nodules with the highest spatial resolution and spectral contrast to date, directly correlated to histopathology, pushing the clinical translation of MSOT.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Multispectral Optoacoustic Tomography ; Optoacoustic ; Photoacoustic ; Thyroid Cancer ; Thyroid Nodule; Photoacoustic Tomography; Association Guidelines; Ex-vivo; Cancer; Management; Carcinoma; Incidentalomas; Ultrasound; Shrinkage; Extension
ISSN (print) / ISBN 1619-7070
e-ISSN 1432-105X
Zeitschrift European Journal of Nuclear Medicine and Molecular Imaging
Quellenangaben Band: 50, Heft: 9, Seiten: 2736-2750 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Institute of Computational Biology (ICB)
Förderungen European Research Council (ERC) under the European Union
Deutsche Forschungsgemeinschaft (DFG)
Foundation de Cock-Hadders