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Bärthel, S.* ; Falcomatà, C.* ; Rad, R.* ; Theis, F.J. ; Saur, D.*

Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.

Nat. Cancer 4, 454-467 (2023)
Postprint DOI PMC
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a heterogeneous genetic landscape and an immunosuppressive tumor microenvironment. Recent advances in high-resolution single-cell sequencing and spatial transcriptomics technologies have enabled an in-depth characterization of both malignant and host cell types and increased our understanding of the heterogeneity and plasticity of PDAC in the steady state and under therapeutic perturbation. In this Review we outline single-cell analyses in PDAC, discuss their implications on our understanding of the disease and present future perspectives of multimodal approaches to elucidate its biology and response to therapy at the single-cell level.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Ductal Adenocarcinoma; Fibroblasts; Tumor; Rna; Immunosuppression; Subtypes; Microenvironment; Inhibition; Genomics; Seq
ISSN (print) / ISBN 2662-1347
e-ISSN 2662-1347
Zeitschrift Nature Cancer
Quellenangaben Band: 4, Heft: 4, Seiten: 454-467 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen Deutsche Forschungsgemeinschaft
German Cancer Consortium
Wilhelm Sander-Stiftung
European Research Council (ERC CoG )
Cancer Research Institute