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Hoffmann, J.* ; Hans, S.* ; Kraus, M. ; Schaller, J.* ; Schäfer, C.* ; Stahl, D.* ; Anker, S.D.* ; Anton, G. ; Bahls, T.* ; Blankenberg, S.* ; Blumentritt, A.* ; Boldt, L.H.* ; Cordes, S.* ; Desch, S.* ; Doehner, W.* ; Dörr, M.* ; Edelmann, F.* ; Eitel, I.* ; Endres, M.* ; Engelhardt, S.* ; Erdmann, J.* ; Eulenburg, K.* ; Falk, V.* ; Felix, S.B.* ; Frank, D.* ; Franke, T.* ; Frey, N.* ; Friede, T.* ; Geidel, L.* ; Germans, L.* ; Grabmaier, U.* ; Halle, M.* ; Hausleiter, J.* ; Jakobi, V.* ; Jebran, A.F.* ; Jobs, A.* ; Kääb, S.* ; Karakas, M.* ; Katus, H.A.* ; Klatt, A.* ; Knosalla, C.* ; Krebser, J.* ; Landmesser, U.* ; Lee, M.* ; Lehnert, K.* ; Lesser, S.* ; Leyh, K.* ; Lorbeer, R.* ; Mach-Kolb, S. ; Meder, B.* ; Nagel, E.* ; Nolte, C.H.* ; Parwani, A.S.* ; Petersmann, A.* ; Puls, M.* ; Rau, H.* ; Reiser, M.* ; Rienhoff, O.* ; Scharfe, T.* ; Schattschneider, M.* ; Scheel, H.* ; Schnabel, R.B.* ; Schuster, A.* ; Schmitt, B.* ; Seidler, T.* ; Seiffert, M.* ; Stähli, B.E.* ; Stas, A.* ; J Stocker, T.* ; von Stülpnagel, L.* ; Thiele, H.* ; Wachter, R.* ; Wakili, R.* ; Weis, T.* ; Weitmann, K.* ; Wichmann, H.-E. ; Wild, P.* ; Zeller, T.* ; Hoffmann, W.* ; Zeisberg, E.M.* ; Zimmermann, W.H.* ; Krefting, D.* ; Kühne, T.* ; Peters, A. ; Hasenfuß, G.* ; Massberg, S.* ; Sommer, T.* ; Dimmeler, S.* ; Eschenhagen, T.* ; Nauck, M.*

The DZHK research platform: Maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.

Clin. Res. Cardiol. 112, 923-941 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics that impact the lives of people with cardiovascular disease. Therefore, DZHK members designed a collaboratively organised and integrated research platform connecting all sites and partners. The overarching objectives of the research platform are the standardisation of prospective data and biological sample collections among all studies and the development of a sustainable centrally standardised storage in compliance with general legal regulations and the FAIR principles. The main elements of the DZHK infrastructure are web-based and central units for data management, LIMS, IDMS, and transfer office, embedded in a framework consisting of the DZHK Use and Access Policy, and the Ethics and Data Protection Concept. This framework is characterised by a modular design allowing a high standardisation across all studies. For studies that require even tighter criteria additional quality levels are defined. In addition, the Public Open Data strategy is an important focus of DZHK. The DZHK operates as one legal entity holding all rights of data and biological sample usage, according to the DZHK Use and Access Policy. All DZHK studies collect a basic set of data and biosamples, accompanied by specific clinical and imaging data and biobanking. The DZHK infrastructure was constructed by scientists with the focus on the needs of scientists conducting clinical studies. Through this, the DZHK enables the interdisciplinary and multiple use of data and biological samples by scientists inside and outside the DZHK. So far, 27 DZHK studies recruited well over 11,200 participants suffering from major cardiovascular disorders such as myocardial infarction or heart failure. Currently, data and samples of five DZHK studies of the DZHK Heart Bank can be applied for.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cardiovascular Disease ; Data And Biomaterial Collection ; German Centre For Cardiovascular Research ; Research Platform ; Standardisation; Risk Postinfarction Patients; Translational Registry; Ejection Fraction; Management; Rationale; Design
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1861-0684
e-ISSN 1861-0692
Zeitschrift Clinical Research in Cardiology
Quellenangaben Band: 112, Heft: 7, Seiten: 923-941 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-004
G-504000-010
Förderungen Diasys
medpoint GmbH
MDI Limbach
Sysmex
Deutsche Akkreditierungsstelle
German Research Foundation
German National Cohort
German Society for Clinical Chemistry and Laboratory Medicine
German Centre for Cardiovascular Research
German Medical Association
Projekt DEAL
AstraZeneca
Novartis
Boehringer Ingelheim
DFG
Medtronic
European Union
BMBF
DZHK
Governments of the Federal States
Federal Ministry of Research and Education
Pharmacosmos
Daiichi-Sankyo
Adrenomed AG
Else Kroner-Fresenius-Stiftung (Else Kroner Clinician Scientist Professorship)
German Center for Neurodegenerative Diseases
German Ministry of Research and Education
Neosoft Ltd.
Bayer Healthcare
Bayer
Amgen
Abbott
Aerocom GmbH
Vifor Pharma
German Center for Cardiovascular Research
German Ministry of Education and Research
EU (Horizon2020)
Boston Scientific
Abbott Vascular
Vifor
Fondation Leducq
Roche Diagnostics
LabNet Laborsysteme GmbH
Profil Institut fur Stoffwechselforschung GmbH
ZS Pharma
DOI 10.1007/s00392-023-02177-5
WOS ID 000952642100001
Scopus ID 85149522828
PubMed ID 36884078
Erfassungsdatum 2023-10-06
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