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Zhao, J.H.* ; Stacey, D.* ; Eriksson, N.* ; Macdonald-Dunlop, E.* ; Hedman, * ; Kalnapenkis, A.* ; Enroth, S.* ; Cozzetto, D.* ; Digby-Bell, J.* ; Marten, J.* ; Folkersen, L.* ; Herder, C.* ; Jonsson, L.* ; Bergen, S.E.* ; Gieger, C. ; Needham, E.J.* ; Surendran, P.* ; Paul, D.S.* ; Polasek, O.* ; Thorand, B. ; Grallert, H. ; Roden, M.* ; Võsa, U.* ; Esko, T.* ; Hayward, C.* ; Johansson, * ; Gyllensten, U.* ; Powell, N.* ; Hansson, O.* ; Mattsson-Carlgren, N.* ; Joshi, P.K.* ; Danesh, J.* ; Padyukov, L.* ; Klareskog, L.* ; Landen, M.* ; Wilson, J.F.* ; Siegbahn, A.* ; Wallentin, L.* ; Mälarstig, A.* ; Butterworth, A.S.* ; Peters, J.E.*

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Nat. Immunol. 24, 1540-1551 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-α in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis versus multiple sclerosis and inflammatory bowel disease. MR implicated CXCL5 in the etiology of ulcerative colitis (UC) and we show elevated gut CXCL5 transcript expression in patients with UC. These results identify targets of existing drugs and provide a powerful resource to facilitate future drug target prioritization.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Growth; Expression; Arthritis; Antibody; Receptor; Tweak; Gwas; Eqtl
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Zeitschrift Nature Immunology
Quellenangaben Band: 24, Heft: 9, Seiten: 1540-1551 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-004
G-504000-002
G-504091-002
Förderungen Wellcome Trust
DOI 10.1038/s41590-023-01588-w
WOS ID 001046606600005
Scopus ID 85167517759
PubMed ID 37563310
Erfassungsdatum 2023-10-06
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