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Hvidtfeldt, U.A.* ; Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Forastiere, F.* ; Brynedal, B.* ; Hertel, O.* ; Hoffmann, B.* ; Katsouyanni, K.* ; Ketzel, M.* ; Leander, K.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Rizzuto, D.* ; Samoli, E.* ; So, R.* ; Stafoggia, M.* ; Tjønneland, A.* ; Weinmayr, G.* ; Wolf, K. ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.*

Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts.

Environ. Res. 239:117230 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated. Methods: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10−5 m−1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3. Conclusions: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Multiple Myeloma ; Nitrogen Dioxide ; Ozone ; Particulate Matter; Cancer; Men; Completeness; Population; Dioxide; Smoking; Models; Health; Women; Pm2.5
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0013-9351
e-ISSN 1096-0953
Zeitschrift Environmental Research
Quellenangaben Band: 239, Heft: Pt 1, Seiten: , Artikelnummer: 117230 Supplement: ,
Verlag Elsevier
Verlagsort San Diego, Calif.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-001
Förderungen United States Environmental Protection Agency (EPA)
DOI 10.1016/j.envres.2023.117230
WOS ID 001098737500001
Scopus ID 85173259485
PubMed ID 37806476
Erfassungsdatum 2023-10-18
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