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Dilger, M.* ; Armant, O.* ; Ramme, L.* ; Mülhopt, S.* ; Sapcariu, S.C.* ; Schlager, C.* ; Dilger, E.* ; Reda, A. ; Orasche, J. ; Schnelle-Kreis, J. ; Conlon, T.M. ; Yildirim, A.Ö. ; Hartwig, A.* ; Zimmermann, R. ; Hiller, K.* ; Diabaté, S.* ; Paur, H.R.* ; Weiss, C.*

Systems toxicology of complex wood combustion aerosol reveals gaseous carbonyl compounds as critical constituents.

Environ. Int. 179:108169 (2023)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Epidemiological studies identified air pollution as one of the prime causes for human morbidity and mortality, due to harmful effects mainly on the cardiovascular and respiratory systems. Damage to the lung leads to several severe diseases such as fibrosis, chronic obstructive pulmonary disease and cancer. Noxious environmental aerosols are comprised of a gas and particulate phase representing highly complex chemical mixtures composed of myriads of compounds. Although some critical pollutants, foremost particulate matter (PM), could be linked to adverse health effects, a comprehensive understanding of relevant biological mechanisms and detrimental aerosol constituents is still lacking. Here, we employed a systems toxicology approach focusing on wood combustion, an important source for air pollution, and demonstrate a key role of the gas phase, specifically carbonyls, in driving adverse effects. Transcriptional profiling and biochemical analysis of human lung cells exposed at the air–liquid-interface determined DNA damage and stress response, as well as perturbation of cellular metabolism, as major key events. Connectivity mapping revealed a high similarity of gene expression signatures induced by wood smoke and agents prompting DNA-protein crosslinks (DPCs). Indeed, various gaseous aldehydes were detected in wood smoke, which promote DPCs, initiate similar genomic responses and are responsible for DNA damage provoked by wood smoke. Hence, systems toxicology enables the discovery of critical constituents of complex mixtures i.e. aerosols and highlights the role of carbonyls on top of particulate matter as an important health hazard.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Air Pollution ; Air–liquid Interface ; Carbonyl Compounds ; Lung Cells ; Systems Toxicology ; Wood Smoke; Air-liquid Interface; Particulate Matter; Connectivity Map; Dna-damage; Pollution; Repair; Cells; Toxicity; Exposure; Toxicogenomics
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Zeitschrift Environment International
Quellenangaben Band: 179, Heft: , Seiten: , Artikelnummer: 108169 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Cooperation Group Comprehensive Molecular Analytics (CMA)
Institute of Lung Biology (LHI)
Helmholtz AI - KIT (HAI - KIT)
Förderungen European Commission's 7th Framework Program research infrastructure project QualityNano
Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health (HICE) via the Helmholtz Association of German Research Centers (HGF)