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Fritsche, A.

Einfache Einteilung der Subtypen des Diabetes in der Praxis.Ein Kommentar.

Simple diabetes subtype classification in clinical practice: A commentary.

Diabetologie 19, 112-116 (2023)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Diabetes mellitus is a complex disease with different pathophysiological causes. Research in recent years has described various pheno- and genotypically defined subgroups for both prediabetes and diabetes. Question: For everyday clinical practice, it is essential to recognize the different phenotypes. It is proposed to do this using a simple measurement of endogenous insulin secretion. Materials and methods: The fasting C‑peptide/glucose ratio (CGR) can be used to estimate endogenous insulin secretion. A prerequisite for this is preserved kidney function (GFR > 50 ml/min/1.73 m2). Results: Autoimmune diabetes and its subtypes can be recognized by a low C‑peptide/glucose ratio, representing a lack of endogenous insulin secretion. A low CGR also describes severe insulin-deficient diabetes (SIDD). In contrast, severe insulin-resistant diabetes (SIRD) is characterized by a high CGR, which is equivalent to insulin hypersecretion. Conclusion: The C‑peptide/glucose ratio allows a simple assessment of different pathophysiological forms of diabetes. Importantly, it can also provide additional information on the need for insulin therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter C‑peptide ; Diabetes Classification ; Glucose Metabolism Disorders ; Insulin Secretion ; Insulin, Therapy
ISSN (print) / ISBN 2731-7447
e-ISSN 2731-7455
Zeitschrift Diabetologie, Die
Quellenangaben Band: 19, Heft: 2, Seiten: 112-116 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)