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Folding makes an imprint.
Genes Dev. 37, 779-780 (2023)
Imprinted gene clusters are confined genomic regions containing genes with parent-of-origin-dependent transcriptional activity. In this issue of Genes & Development, Loftus and colleagues (pp. 829-843) made use of an insightful combination of descriptive approaches, genetic manipulations, and epigenome-editing approaches to show that differences in nuclear topology precede the onset of imprinted expression at the Peg13-Kcnk9 locus. Furthermore, the investigators provide data in line with a model suggesting that parent-of-origin-specific topological differences could be responsible for parent-of-origin-specific enhancer activity and thus imprinted expression.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Chromatin Structure ; Epigenetics ; Genomic Imprinting ; Neuron Differentiation
ISSN (print) / ISBN
0890-9369
e-ISSN
1549-5477
Zeitschrift
Genes and Development
Quellenangaben
Band: 37,
Heft: 17-18,
Seiten: 779-780
Verlag
Cold Spring Harbor Laboratory Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)