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Zhong, J.* ; Aires, R.* ; Tsissios, G.* ; Skoufa, E.* ; Brandt, K. ; Sandoval-Guzmán, T. ; Aztekin, C.*

Multi-species atlas resolves an axolotl limb development and regeneration paradox.

Nat. Commun. 14:6346 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, and AER-like cells are suggested to be re-formed to initiate limb regeneration. Paradoxically, the presence of AER in the axolotl, a primary model organism for regeneration, remains controversial. Here, by leveraging a single-cell transcriptomics-based multi-species atlas, composed of axolotl, human, mouse, chicken, and frog cells, we first establish that axolotls contain cells with AER characteristics. Further analyses and spatial transcriptomics reveal that axolotl limbs do not fully re-form AER cells during regeneration. Moreover, the axolotl mesoderm displays part of the AER machinery, revealing a program for limb (re)growth. These results clarify the debate about the axolotl AER and the extent to which the limb developmental program is recapitulated during regeneration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Expression Patterns; Cell-proliferation; Gene-expression; Epidermal Cap; Amputation; Inhibition; Urodele; Origin
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 6346 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-001
Förderungen Von Humboldt Foundation Research fellowship
SNSF
Foundation Gabriella Giorgi-Cavaglieri, Branco Weiss Fellowship
A. Petzold and the CM
M. Ros, D. Suter, G. La Manno, and M. Gurel for their critical reading of the manuscript
M. Gurel and M. Brbic for discussions on factorization and module identification
We thank Aztekin and Sandoval-Guzman Labs for the discussions
DOI 10.1038/s41467-023-41944-w
WOS ID 001095507700006
Scopus ID 85173611913
PubMed ID 37816738
Erfassungsdatum 2023-11-28
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