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Kiewiet, M.B.G.* ; Lupinek, C.* ; Vrtala, S.* ; Wieser, S.* ; Baar, A.* ; Kiss, R.* ; Kull, I.* ; Melén, E.* ; Wickman, M.* ; Porta, D.* ; Gori, D.* ; Gehring, U.* ; Aalberse, R.* ; Sunyer, J.* ; Standl, M. ; Heinrich, J.* ; Waiblinger, D.* ; Wright, J.* ; Antò, J.M.* ; Bousquet, J.* ; van Hage, M.* ; Valenta, R.*

A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles.

Allergy 78, 2007-2018 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
BACKGROUND: Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy. METHODS: Immunoglobulin E (IgE) sensitization profiles were determined in more than 2800 sera from children in nine population-based cohorts in different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB (the United Kingdom), GINIplus (Germany)], and south [INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)] using the MeDALL-allergen chip. RESULTS: Sensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5-sensitization dominated in North and West/Central Europe. CONCLUSION: We show regional, exposome- and climate-dependent differences in molecular IgE-reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine-based approaches for treatment and prevention of allergy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Europe ; Ige Reactivity ; Medall Chip ; Allergen Molecules ; Exposome ; Sensitization Profile
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 78, Heft: 7, Seiten: 2007-2018 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-008
Förderungen European Commission
DOI 10.1111/all.15689
PubMed ID 36815272
Erfassungsdatum 2024-03-12
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