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Meyer, N.M.T.* ; Pohrt, A.* ; Wernicke, C.* ; Pletsch-Borba, L.* ; Apostolopoulou, K.* ; Haberbosch, L.* ; Machann, J. ; Pfeiffer, A.F.H.* ; Spranger, J.* ; Mai, K.*

Improvement in visceral adipose tissue and LDL cholesterol by high PUFA intake: 1-year results of the NutriAct trial.

Nutrients 16:1057 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
We assessed the effect of a dietary pattern rich in unsaturated fatty acids (UFA), protein and fibers, without emphasizing energy restriction, on visceral adipose tissue (VAT) and cardiometabolic risk profile. Within the 36-months randomized controlled NutriAct trial, we randomly assigned 502 participants (50-80 years) to an intervention or control group (IG, CG). The dietary pattern of the IG includes high intake of mono-/polyunsaturated fatty acids (MUFA/PUFA 15-20% E/10-15% E), predominantly plant protein (15-25% E) and fiber (≥30 g/day). The CG followed usual care with intake of 30% E fat, 55% E carbohydrates and 15% E protein. Here, we analyzed VAT in a subgroup of 300 participants via MRI at baseline and after 12 months, and performed further metabolic phenotyping. A small but comparable BMI reduction was seen in both groups (mean difference IG vs. CG: -0.216 kg/m2 [-0.477; 0.045], partial η2 = 0.009, p = 0.105). VAT significantly decreased in the IG but remained unchanged in the CG (mean difference IG vs. CG: -0.162 L [-0.314; -0.011], partial η2 = 0.015, p = 0.036). Change in VAT was mediated by an increase in PUFA intake (ß = -0.03, p = 0.005) and induced a decline in LDL cholesterol (ß = 0.11, p = 0.038). The NutriAct dietary pattern, particularly due to high PUFA content, effectively reduces VAT and cardiometabolic risk markers, independent of body weight loss.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ldl Cholesterol ; Nutriact ; Healthy Aging ; Polyunsaturated Fatty Acid ; Visceral Adipose Tissue; Cardiovascular Risk-factors; Weight-loss; Insulin Sensitivity; Body-composition; Liver Fat; Model Assessment; Abdominal Fat; Dietary; Obesity; Protein
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Zeitschrift Nutrients
Quellenangaben Band: 16, Heft: 7, Seiten: , Artikelnummer: 1057 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen Berlin University Alliance under the Program Line Grand Challenges 1: Social Cohesion, Exploratory Projects
Excellence Initiative of the Federal Government
German Federal Ministry for Education and Research (BMBF) by support of the German Center for Cardiovascular Research (DZHK)
German Federal Ministry of Education and Research(BMBF)
German Federal Ministry for Education and Research(BMBF)
DOI 10.3390/nu16071057
WOS ID 001201010000001
PubMed ID 38613089
Erfassungsdatum 2024-06-04
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