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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Thermal proteome profiling reveals insight to antiproliferative and pro-apoptotic effects of Lagunamide A in the modulation of DNA damage repair.
ChemBioChem:e202400024 (2024)
Lagunamide A is a biologically active natural product with a yet unidentified molecular mode of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell proliferation, promotes apoptosis and causes mitochondrial dysfunction. To decipher the cellular mechanism responsible for these effects, we utilized thermal protein profiling (TPP) and identified EYA3 as a stabilized protein in cells upon lagunamide A treatment. EYA3, involved in the DNA damage repair process, was functionally investigated via siRNA based knockdown studies and corresponding effects of lagunamide A on DNA repair were confirmed. Furthermore, we showed that lagunamide A sensitized tumor cells to treatment with the drug doxorubicin highlighting a putative therapeutic strategy.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Affinity Based Protein Profiling ; Dna Damage ; Lagunamide A ; Tpp ; Thermal Protein Profiling; Cancer; Dephosphorylation; Identification; Survival; Binding; Eya3
ISSN (print) / ISBN
1439-4227
e-ISSN
1439-7633
Zeitschrift
ChemBioChem
Quellenangaben
Artikelnummer: e202400024
Verlag
Wiley
Verlagsort
Postfach 101161, 69451 Weinheim, Germany
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Förderungen
Merck Future Insight Prize
Chinese Scholarship Council (CSC)
Chinese Scholarship Council (CSC)