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Stoleriu, M.-G. ; Pienn, M.* ; Joerres, R.A.* ; Alter, P.* ; Fero, T.* ; Urschler, M.* ; Kovács, G.* ; Olschewski, H.* ; Kauczor, H.U.* ; Wielpütz, M.O.* ; Jobst, B.* ; Welte, T.* ; Behr, J. ; Trudzinski, F.C.* ; Bals, R.* ; Watz, H.* ; Vogelmeier, C.F.* ; Biederer, J.* ; Kahnert, K.

Expiratory venous volume and arterial tortuosity are associated with disease severity and mortality risk in patients with COPD: Results from COSYCONET.

Int. J. Chron. Obstruct. Pulmon. Dis. 19, 1515-1529 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
PURPOSE: The aim of this study was to evaluate the association between computed tomography (CT) quantitative pulmonary vessel morphology and lung function, disease severity, and mortality risk in patients with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: Participants of the prospective nationwide COSYCONET cohort study with paired inspiratory-expiratory CT were included. Fully automatic software, developed in-house, segmented arterial and venous pulmonary vessels and quantified volume and tortuosity on inspiratory and expiratory scans. The association between vessel volume normalised to lung volume and tortuosity versus lung function (forced expiratory volume in 1 sec [FEV1]), air trapping (residual volume to total lung capacity ratio [RV/TLC]), transfer factor for carbon monoxide (TLCO), disease severity in terms of Global Initiative for Chronic Obstructive Lung Disease (GOLD) group D, and mortality were analysed by linear, logistic or Cox proportional hazard regression. RESULTS: Complete data were available from 138 patients (39% female, mean age 65 years). FEV1, RV/TLC and TLCO, all as % predicted, were significantly (p < 0.05 each) associated with expiratory vessel characteristics, predominantly venous volume and arterial tortuosity. Associations with inspiratory vessel characteristics were absent or negligible. The patterns were similar for relationships between GOLD D and mortality with vessel characteristics. Expiratory venous volume was an independent predictor of mortality, in addition to FEV1. CONCLUSION: By using automated software in patients with COPD, clinically relevant information on pulmonary vasculature can be extracted from expiratory CT scans (although not inspiratory scans); in particular, expiratory pulmonary venous volume predicted mortality. TRIAL REGISTRATION: NCT01245933.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Copd ; Computed Tomography ; Lung Function ; Pulmonary Vasculature ; Vessel Tortuosity ; Vessel Volume; Obstructive Pulmonary-disease; Vascular Volume; Hypertension; Ct; Prediction; Enlargement; Emphysema; Vessels; Chest; Age
ISSN (print) / ISBN 1176-9106
e-ISSN 1178-2005
Zeitschrift International Journal of Chronic Obstructive Pulmonary Disease
Quellenangaben Band: 19, Heft: , Seiten: 1515-1529 Artikelnummer: , Supplement: ,
Verlag Dove Medical Press
Verlagsort Albany, Auckland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Lung Health and Immunity (LHI)
Förderungen Teva GmbH
Takeda Pharma Vertrieb GmbH Co. KG
Pfizer Pharma GmbH
Novartis Deutschland GmbH
Mundipharma GmbH
MSD Sharp Dohme GmbH
AstraZeneca GmbH
BMBF
German Federal Ministry of Education and Research (BMBF) Competence Network Asthma and COPD (ASCONET)