PuSH - Publikationsserver des Helmholtz Zentrums München: Expiratory venous volume and arterial tortuosity are associated with disease severity and mortality risk in patients with COPD: Results from COSYCONET.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Stoleriu, M.-G. ; Pienn, M.* ; Joerres, R.A.* ; Alter, P.* ; Fero, T.* ; Urschler, M.* ; Kovács, G.* ; Olschewski, H.* ; Kauczor, H.U.* ; Wielpütz, M.O.* ; Jobst, B.* ; Welte, T.* ; Behr, J. ; Trudzinski, F.C.* ; Bals, R.* ; Watz, H.* ; Vogelmeier, C.F.* ; Biederer, J.* ; Kahnert, K.

Expiratory venous volume and arterial tortuosity are associated with disease severity and mortality risk in patients with COPD: Results from COSYCONET.

Int. J. Chron. Obstruct. Pulmon. Dis. 19, 1515-1529 (2024)

Verlagsversion

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

PURPOSE: The aim of this study was to evaluate the association between computed tomography (CT) quantitative pulmonary vessel morphology and lung function, disease severity, and mortality risk in patients with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: Participants of the prospective nationwide COSYCONET cohort study with paired inspiratory-expiratory CT were included. Fully automatic software, developed in-house, segmented arterial and venous pulmonary vessels and quantified volume and tortuosity on inspiratory and expiratory scans. The association between vessel volume normalised to lung volume and tortuosity versus lung function (forced expiratory volume in 1 sec [FEV₁]), air trapping (residual volume to total lung capacity ratio [RV/TLC]), transfer factor for carbon monoxide (TLCO), disease severity in terms of Global Initiative for Chronic Obstructive Lung Disease (GOLD) group D, and mortality were analysed by linear, logistic or Cox proportional hazard regression. RESULTS: Complete data were available from 138 patients (39% female, mean age 65 years). FEV₁, RV/TLC and TLCO, all as % predicted, were significantly (p < 0.05 each) associated with expiratory vessel characteristics, predominantly venous volume and arterial tortuosity. Associations with inspiratory vessel characteristics were absent or negligible. The patterns were similar for relationships between GOLD D and mortality with vessel characteristics. Expiratory venous volume was an independent predictor of mortality, in addition to FEV₁. CONCLUSION: By using automated software in patients with COPD, clinically relevant information on pulmonary vasculature can be extracted from expiratory CT scans (although not inspiratory scans); in particular, expiratory pulmonary venous volume predicted mortality. TRIAL REGISTRATION: NCT01245933.

Impact Factor

Scopus SNIP

Altmetric

2.700

0.000