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Chen, B.* ; de Launoit, E.* ; Meseguer, D.* ; García-Cáceres, C. ; Eichmann, A.* ; Renier, N.* ; Schneeberger, M.*

The interactions between energy homeostasis and neurovascular plasticity.

Nat. Rev. Endocrinol., DOI: 10.1038/s41574-024-01021-8 (2024)
Verlagsversion Postprint DOI PMC
Open Access Green
Food intake and energy expenditure are sensed and processed by multiple brain centres to uphold energy homeostasis. Evidence from the past decade points to the brain vasculature as a new critical player in regulating energy balance that functions in close association with the local neuronal networks. Nutritional imbalances alter many properties of the neurovascular system (such as neurovascular coupling and blood-brain barrier permeability), thus suggesting a bidirectional link between the nutritional milieu and neurovascular health. Increasing numbers of people are consuming a Western diet (comprising ultra-processed food with high-fat and high-sugar content) and have a sedentary lifestyle, with these factors contributing to the current obesity epidemic. Emerging pharmacological interventions (for example, glucagon-like peptide 1 receptor agonists) successfully trigger weight loss. However, whether these approaches can reverse the detrimental effects of long-term exposure to the Western diet (such as neurovascular uncoupling, neuroinflammation and blood-brain barrier disruption) and maintain stable body weight in the long-term needs to be clarified in addition to possible adverse effects. Lifestyle interventions revert the nutritional trigger for obesity and positively affect our overall health, including the cardiovascular system. This Perspective examines how lifestyle interventions affect the neurovascular system and neuronal networks.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cerebral-blood-flow; Brain Glucose-uptake; High-fat Diet; Life-style; Cerebrovascular Reactivity; Body-composition; Restriction; Obesity; Barrier; Lactate
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Zeitschrift Nature Reviews - Endocrinology
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-224
Förderungen National Institute of Diabetes, Digestive and Kidney Diseases
Interstellar Initiative (NYAS/AMED)
E. Matilda Ziegler Foundation
McCluskey family
DOI 10.1038/s41574-024-01021-8
WOS ID 001276020400001
Scopus ID 85199750505
PubMed ID 39054359
Erfassungsdatum 2024-07-29
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