PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Decoster, L.* ; Trova, S.* ; Zucca, S.* ; Bulk, J.* ; Gouveia, A.* ; Ternier, G.* ; Lhomme, T.* ; Legrand, A.* ; Gallet, S.* ; Boehm, U.* ; Wyatt, A.* ; Wahl, V.* ; Wartenberg, P.* ; Hrabovszky, E.* ; Rácz, G.* ; Luzzati, F.* ; Nato, G.* ; Fogli, M.* ; Peretto, P.* ; Schriever, S.C. ; Bernecker, M. ; Pfluger, P.T. ; Steculorum, S.M.* ; Bovetti, S.* ; Rasika, S.* ; Prévot, V.* ; Silva, M.S.B.* ; Giacobini, P.*

A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.

Nat. Neurosci. 27, 1758-1773 (2024)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and integrate hormonal status with environmental cues to ensure reproductive success. Here we show that GnRH neurons in the olfactory bulb (GnRHOB) of adult mice can mediate social recognition. Specifically, we show that GnRHOB neurons extend neurites into the vomeronasal organ and olfactory epithelium and project to the median eminence. GnRHOB neurons in males express vomeronasal and olfactory receptors, are activated by female odors and mediate gonadotropin release in response to female urine. Male preference for female odors required the presence and activation of GnRHOB neurons, was impaired after genetic inhibition or ablation of these cells and relied on GnRH signaling in the posterodorsal medial amygdala. GnRH receptor expression in amygdala kisspeptin neurons appear to be required for GnRHOB neurons' actions on male mounting behavior. Taken together, these results establish GnRHOB neurons as regulating fertility, sex recognition and mating in male mice.
Impact Factor
Scopus SNIP
Altmetric
21.300
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Luteinizing-hormone Secretion; Hypogonadotropic Hypogonadism; Corticomedial Amygdala; Vomeronasal Organ; Golden-hamster; Feedback; Recognition; Connections; Projections; Activation
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Zeitschrift Nature Neuroscience
Quellenangaben Band: 27, Heft: 9, Seiten: 1758-1773 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502294-001
Förderungen Agence Nationale de la Recherche (ANR)
Lille In vivo Imaging and Functional Exploration platform (Univ.)
CNRS
Inserm, CHU Lille
Institut Pasteur of Lille
European Research Council under the European Union's Horizon 2020 Research and Innovation program
Agence Nationale de la Recherche
INSERM-France
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
DOI 10.1038/s41593-024-01724-1
WOS ID 001282667200001
Scopus ID 85200406517
PubMed ID 39095587
Erfassungsdatum 2024-09-24
[➜Korrektur melden]