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Zhang, W.* ; Zhang, S.* ; Knoedler, S.* ; Han, W.* ; Zha, K.* ; Li, H.* ; Christine Panayi, A.* ; Alfertshofer, M.* ; Kim, B.S.* ; Hu, W.* ; Zhao, Y.* ; Feng, Q.* ; Rinkevich, Y. ; Mi, B.* ; Liu, G.*

Hybrid biomaterial hydrogel loading iRGD&PS double modified lipid nanoparticles ameliorates diabetic wound healing through promoting efferocytosis and glycolysis-related macrophage reprogramming.

Chem. Eng. J. 497:154800 (2024)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Efferocytosis is a critical process whereby macrophages residing in the wound area play a key role in the efficient clearing and degradation of apoptotic neutrophils. This process is followed by a phenotypic transition toward an anti-inflammatory state, essential for inflammation resolution and tissue repair. The cystine/glutamate antiporter SLC7A11 has recently been identified as an inhibitor of efferocytosis, and its blockade has been found to enhance wound healing. In this study, we demonstrated that tiliroside, a plant-derived glycoside containing flavones, binds directly to SLC7A11 and pyruvate kinase isozyme M2 (PKM2). This was established by molecular docking predictions and activity-based protein profiling (ABPP). Cytological experiments revealed that tiliroside promoted the process of efferocytosis and led to glycolysis-related macrophage reprogramming. To facilitate targeted drug delivery to macrophages at diabetic wound sites, we designed a novel hybrid biomaterial. This hybrid biomaterial, prepared as Gel@Til iRGD&PS@PLGA NPs is manufactured by loading tiliroside (Til)-conjugated iRGD&PS double modified lipid nanoparticles (iRGD&PS@PLGA NPs) into a pH-responsive hydrogel matrix. The administration of Gel@Til iRGD&PS@PLGA NPs in diabetic cutaneous wound models has been shown to significantly promote tissue regeneration through the promotion of efferocytosis and glycolysis-related macrophage reprogramming. Therefore, this study introduces a novel approach to diabetic wound management by leveraging the promotion of efferocytosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Biomaterials ; Diabetic Wound Healing ; Efferocytosis ; Hydrogels ; Macrophage Reprogramming ; Wound Healing; Foot Ulcers; Tiliroside; Inflammation; Proliferation; Hif-1-alpha; Resolution; Netosis
ISSN (print) / ISBN 1385-8947
Zeitschrift Chemical Engineering Journal
Quellenangaben Band: 497, Heft: , Seiten: , Artikelnummer: 154800 Supplement: ,
Verlag Elsevier
Verlagsort Po Box 564, 1001 Lausanne, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology (IRBM)
Förderungen Hubei Province Unveiling Science and Technology Projects
Wuhan Science and Tech-nology Bureau
National Science Foundation of China