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Hansen, F.J.* ; Mittelstädt, A.* ; Clausen, F.N.* ; Knoedler, S. ; Knoedler, L.* ; Klöckner, S.* ; Kuchenreuther, I.* ; Mazurie, J.* ; Arnold, L.S.* ; Anthuber, A.* ; Jacobsen, A.V.* ; Merkel, S.* ; Weisel, N.* ; Klösch, B.* ; Karabiber, A.* ; Tacyildiz, I.* ; Czubayko, F.* ; Reitberger, H.* ; Gendy, A.E.* ; Brunner, M.* ; Krautz, C.* ; Wolff, K.* ; Mihai, S.* ; Neufert, C.* ; Siebler, J.* ; Grützmann, R.* ; Weber, G.F.* ; David, P.*

CD71 expressing circulating neutrophils serve as a novel prognostic biomarker for metastatic spread and reduced outcome in pancreatic ductal adenocarcinoma patients.

Sci. Rep. 14:21164 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, presenting a persisting global health burden. Neutrophils have a double-edged role in tumor progression exhibiting both pro-tumor and anti-tumor functions. CD71, also known as transferrin receptor 1, performs a critical role in cellular iron uptake and is highly expressed on proliferating cells, and especially on activated immune cells. CD71 is known to be elevated in various types of solid cancers and is associated with poor prognosis, however, the expression of CD71 on neutrophils in PDAC and its potential clinical impact is still unknown. Therefore, we analyzed CD71 on circulating neutrophils in PDAC and clinical control patients and found a significant increased expression in PDAC patients. High expression of CD71 on neutrophils in PDAC patients was associated with reduced outcome compared to low expression. CD71 on neutrophils correlated positively with the levels of proinflammatory cytokines IL-6, IFN-γ, and growth factor ligands CD40-L, and BAFF in plasma of PDAC patients. Finally, we have demonstrated that high expression of CD71 on neutrophils was also associated with an increased expression of CD39 and CD25 on circulating T-cells. Based on our findings, we hypothesize that CD71 on neutrophils is associated with tumor progression in PDAC. Further studies are required to investigate the distinct functionality of CD71 expressing neutrophils and their potential clinical application.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cd71 ; Metastatic Spread ; Neutrophils ; Pancreatic Ductal Adenocarcinoma ; Prognostic Biomarker ; Transferrin Receptor 1; Transferrin Receptor Cd71; Ifn-gamma; T-cells; Cancer; Lymphocyte; Roles
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 21164 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology (IRBM)
Förderungen Deutsche Forschungsgemeinschaft