PuSH - Publikationsserver des Helmholtz Zentrums München: Remote neuroinflammation in newly diagnosed glioblastoma correlates with unfavorable clinical outcome.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Bartos, L.M.* ; Quach, S.* ; Zenatti, V.* ; Kirchleitner, S.V.* ; Blobner, J.* ; Wind-Mark, K.* ; Kolabas, Z.I. ; Ulukaya, S. ; Holzgreve, A.* ; Ruf, V.C.* ; Kunze, L.H.* ; Kunte, S.T.* ; Hoermann, L.* ; Härtel, M.* ; Park, H.E.* ; Groß, M.* ; Franzmeier, N.* ; Zatcepin, A.* ; Zounek, A.* ; Kaiser, L.* ; Riemenschneider, M.J.* ; Perneczky, R.* ; Rauchmann, B.S.* ; Stöcklein, S.* ; Ziegler, S.* ; Herms, J.* ; Ertürk, A. ; Tonn, J.C.* ; Thon, N.* ; von Baumgarten, L.* ; Prestel, M.* ; Tahirovic, S.* ; Albert, N.L.* ; Brendel, M.*

Remote neuroinflammation in newly diagnosed glioblastoma correlates with unfavorable clinical outcome.

Clin. Cancer Res. 30, 4618-4634 (2024)

Verlagsversion

DOI

PMC

	Open Access Hybrid

Abstract
Metriken
Zusatzinfos

PURPOSE: Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in the brain of patients with glioblastoma have been described. However, the impact and molecular signature of neuroinflammation distant of the primary tumor site have not yet been thoroughly elucidated. EXPERIMENTAL DESIGN: We performed translocator protein (TSPO)-PET in patients with newly diagnosed glioblastoma (n = 41), astrocytoma WHO grade 2 (n = 7), and healthy controls (n = 20) and compared TSPO-PET signals of the non-lesion (i.e., contralateral) hemisphere. Back-translation into syngeneic SB28 glioblastoma mice was used to characterize Pet alterations on a cellular level. Ultimately, multiplex gene expression analyses served to profile immune cells in remote brain. RESULTS: Our study revealed elevated TSPO-PET signals in contralateral hemispheres of patients with newly diagnosed glioblastoma compared to healthy controls. Contralateral TSPO was associated with persisting epileptic seizures and shorter overall survival independent of the tumor phenotype. Back-translation into syngeneic glioblastoma mice pinpointed myeloid cells as the predominant source of contralateral TSPO-PET signal increases and identified a complex immune signature characterized by myeloid cell activation and immunosuppression in distant brain regions. CONCLUSIONS: Neuroinflammation within the contralateral hemisphere can be detected with TSPO-PET imaging and associates with poor outcome in patients with newly diagnosed glioblastoma. The molecular signature of remote neuroinflammation promotes the evaluation of immunomodulatory strategies in patients with detrimental whole brain inflammation as reflected by high TSPO expression.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Altmetric

10.400

0.000