PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Janke, C.* ; Rubio-Acero, R.* ; Weigert, M.* ; Reinkemeyer, C.* ; Khazaei, Y.* ; Kleinlein, L.* ; Le Gleut, R. ; Radon, K.* ; Hannes, M. ; Picasso, F.* ; Lucke, A.E.* ; Plank, M.* ; Kotta, I.C.* ; Paunovic, I.* ; Zhelyazkova, A.* ; Noreña, I.* ; Winter, S.* ; Hoelscher, M. ; Wieser, A.* ; Küchenhoff, H.* ; Castelletti, N.

Understanding the omicron variant impact in healthcare workers: Insights from the prospective COVID-19 post-immunization serological cohort in Munich (KoCo-Impf) on risk factors for breakthrough and reinfections.

Viruses 16:1556 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
This study analyzes immune responses to SARS-CoV-2 vaccination and infection, including asymptomatic cases, focusing on infection risks during the Omicron wave, particularly among high-risk healthcare workers. In the KoCo-Impf study, we monitored 6088 vaccinated participants in Munich aged 18 and above. From 13 May to 31 July 2022, 2351 participants were follow-uped. Logistic regression models evaluated primary, secondary, and breakthrough infections (BTIs). Roche Elecsys® Anti-SARS-CoV-2 assays detected prior infections (via anti-Nucleocapsid antibodies) and assessed vaccination/infection impact (via anti-Spike antibodies) using dried blood spots. Our findings revealed an anti-Nucleocapsid seroprevalence of 44.1%. BTIs occurred in 38.8% of participants, with reinfections in 48.0%. Follow-up participation was inversely associated with current smoking and non-vaccination, while significantly increasing with age and receipt of three vaccine doses. Larger household sizes and younger age increased infection risks, whereas multiple vaccinations and older age reduced them. Household size and specific institutional subgroups were risk factors for BTIs. The anti-Nucleocapsid value prior to the second infection was significantly associated with reinfection risk. Institutional subgroups influenced all models, underscoring the importance of tailored outbreak responses. The KoCo-Impf study underscores the importance of vaccination, demographic factors, and institutional settings in understanding SARS-CoV-2 infection risks during the Omicron wave.
Impact Factor
Scopus SNIP
Altmetric
3.800
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Covid-19 ; Orchestra ; Sars-cov-2 ; Antibodies ; Breakthrough Infections ; Health Care Workers ; Immunologic Response ; Reinfections ; Seroprevalence ; Vaccination; Sars-cov-2 Reinfection; Protection
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1999-4915
e-ISSN 1999-4915
Zeitschrift Viruses
Quellenangaben Band: 16, Heft: 10, Seiten: , Artikelnummer: 1556 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
Institute of Computational Biology (ICB)
Research Unit Global Health (UGH)
CF Statistical Consulting (CF-STATCON)
POF Topic(s) 30203 - Molecular Targets and Therapies
30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Radiation Sciences
Enabling and Novel Technologies
PSP-Element(e) G-501391-001
G-503800-001
G-540001-003
A-632200-001
Förderungen German Federal Ministry of Education and Research (BMBF)
European Union
European Union's Horizon 2020 research and innovation program
DOI 10.3390/v16101556
WOS ID 001342963500001
Scopus ID 85207457778
PubMed ID 39459890
Erfassungsdatum 2024-10-31
[➜Korrektur melden]