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Bonilla, W.V.* ; Fröhlich, A.* ; Senn, K.* ; Kallert, S.* ; Fernandez, M.* ; Johnson, S.* ; Kreutzfeldt, M.* ; Hegazy, A.N.* ; Schrick, C.* ; Fallon, P.G.* ; Klemenz, R.* ; Nakae, S.* ; Adler, H. ; Merkler, D.* ; Löhning, M.* ; Pinschewer, D.D.*

The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses.

Science 335, 984-989 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter CHORIOMENINGITIS VIRUS-INFECTION; IL-1-LIKE CYTOKINE IL-33; IN-VIVO; EFFECTOR FUNCTION; IMMUNE-RESPONSES; MICE; EXPRESSION; RECEPTOR; SIGNALS; ST2
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 335, Heft: 6071, Seiten: 984-989 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Hematopoetic Cell Transplants (IMI-KHZ)
Research Unit Gene Vector (AGV)