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Bonilla, W.V.* ; Fröhlich, A.* ; Senn, K.* ; Kallert, S.* ; Fernandez, M.* ; Johnson, S.* ; Kreutzfeldt, M.* ; Hegazy, A.N.* ; Schrick, C.* ; Fallon, P.G.* ; Klemenz, R.* ; Nakae, S.* ; Adler, H. ; Merkler, D.* ; Löhning, M.* ; Pinschewer, D.D.*

The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses.

Science 335, 984-989 (2012)
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Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter CHORIOMENINGITIS VIRUS-INFECTION; IL-1-LIKE CYTOKINE IL-33; IN-VIVO; EFFECTOR FUNCTION; IMMUNE-RESPONSES; MICE; EXPRESSION; RECEPTOR; SIGNALS; ST2
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 335, Heft: 6071, Seiten: 984-989 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Asthma and Allergy Prevention (IAP)
Research Unit Gene Vector (AGV)
CCG Hematopoetic Cell Transplants (IMI-KHZ)
POF Topic(s) 30202 - Environmental Health
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Allergy
Immune Response and Infection
PSP-Element(e) G-503300-001
G-501500-006
G-520300-001
DOI 10.1126/science.1215418
WOS ID WOS:000300931800051
Scopus ID 84857640602
PubMed ID 22323740
Erfassungsdatum 2012-03-08
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