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Kittke, V. ; Zhao, C. ; Lam, D.D. ; Harrer, P. ; Krezel, W.* ; Schormair, B. ; Oexle, K. ; Winkelmann, J.

RLS-associated MEIS transcription factors control distinct processes in human neural stem cells.

Sci. Rep. 14:28986 (2024)
Verlagsversion DOI PMC
Open Access Gold
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MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for developmental processes in a wide range of tissues, including the brain. They can execute redundant functions when co-expressed in the same cell types, but their roles during early stages of neural differentiation have not been systematically compared. By separate knockout and overexpression of MEIS1 and MEIS2 in human neural stem cells, we find they control specific sets of target genes, associated with distinct biological processes. Integration of DNA binding sites with differential transcriptomics implicates MEIS1 to co-regulate gene expression by interaction with transcription factors of the SOX and FOX families. MEIS1 harbors the strongest risk factor for restless legs syndrome (RLS). Our data suggest that MEIS1 can directly regulate the RLS-associated genes NTNG1, MDGA1 and DACH1, constituting new approaches to study the elusive pathomechanism or RLS.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Restless Legs Syndrome; Genome-wide Association; Lateral Ganglionic Eminence; Dna-binding Partners; Medium Spiny Neurons; Homeobox Genes; Pbx; Expression; Proteins; Prep1
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 28986 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Neurogenomics (ING)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503200-001
Förderungen Helmholtz Zentrum Munchen - Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH)
Projekt DEAL
DOI 10.1038/s41598-024-80266-9
WOS ID 001362462000039
Scopus ID 85209711442
PubMed ID 39578497
Erfassungsdatum 2024-12-02
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