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Santiago Franco, M. ; Raulefs, S. ; Schilling, D. ; Combs, S.E. ; Schmid, T.E.

Impact of radiation on invasion and migration of glioma in vitro and in vivo.

Cancers 16:3900 (2024)
Verlagsversion DOI PMC
Free journal
Creative Commons Lizenzvertrag
Glioblastoma (GBM) constitutes the most common primary brain tumor and it remains incurable despite therapeutic advances. The high infiltration/invasion potential of GBM cells is considered to be one of the reasons for the inevitable recurrence of the disease. Radiotherapy (RT) is part of the standard care for patients with GBM, and its benefits on overall survival are extensively reported. However, numerous preclinical studies show that X-ray irradiation can enhance the motility of GBM cells. In the present review, we bring together state-of-the-art research on the impact of radiation on GBM cell motility. The mechanisms through which irradiation impacts the brain tumor microenvironment and the tumor cells themselves, leading to more aggressive/invasive tumors, are described. Finally, we summarize potential pharmacological strategies to overcome this problem. Clinical data validating the occurrence of these processes are urgently needed as they could be of great value for patient outcomes. With this comprehensive review, we expect to highlight the need for methods which allow for monitoring the post-irradiation invasive behavior of GBM in patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Glioblastoma ; Invasion ; Irradiation ; Microenvironment ; Migration ; Motility ; Radiotherapy
ISSN (print) / ISBN 2072-6694
Zeitschrift Cancers
Quellenangaben Band: 16, Heft: 23, Seiten: , Artikelnummer: 3900 Supplement: ,
Verlag MDPI
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)