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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients.
Ann. Oncol. 23, 2185-2190 (2012)
BACKGROUND: Ewing's sarcoma (ES) is the second most common bone or soft-tissue sarcoma in childhood and adolescence and features a high propensity to metastasize. The six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is a membrane-bound mesenchymal stem cell marker highly expressed in ES. Here, we investigated the role of STEAP1 as an immunohistological marker for outcome prediction in patients with ES. PATIENTS AND METHODS: Membranous STEAP1 immunoreactivity was analyzed using immunohistochemistry in 114 primary pre-chemotherapy ES of patients diagnosed from 1983 to 2010 and compared with clinical parameters and patient outcome. Median follow-up was 3.85 years (range 0.43-17.51). RESULTS: A total of 62.3% of the ES samples displayed detectable STEAP1 expression with predominant localization of the protein at the plasma membrane. High membranous STEAP1 immunoreactivity was found in 53.5%, which correlated with better overall survival (P = 0.021). Accordingly, no or low membranous STEAP1 expression was identified as an independent risk factor in multivariate analysis (hazard ratio 2.65, P = 0.036). CONCLUSIONS: High membranous STEAP1 expression predicts improved outcome and may help to define a specific subgroup of ES patients, who might benefit from adapted therapy regimens.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
biomarker; Ewing's sarcoma; outcome; risk stratification; STEAP1; 6-transmembrane Epithelial Antigen ; Long-term Survival ; Stem-cell Rescue ; Breast-cancer ; Nuclear-localization ; Prognostic-factors ; Tumor Patients ; Family Tumors ; Prostate ; Growth
ISSN (print) / ISBN
0923-7534
e-ISSN
1569-8041
Zeitschrift
Annals of Oncology
Quellenangaben
Band: 23,
Heft: 8,
Seiten: 2185-2190
Verlag
Oxford University Press
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed