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Scherer, T.* ; Metz, M.* ; Beghini, M.* ; Bilban, M.* ; Gensthaler, L.* ; Luca, A.C.* ; Kaplanian, M.* ; Abu Eid, S.* ; Koldyka, O.* ; Hackl, M.T.* ; Dürr, S.* ; Rivelles, E.* ; Schönecker, S.S.* ; Pöltl, L.* ; Kaya, A.* ; Chami, R.* ; Nusko, L.* ; Tschare, C.* ; Ablaza, K.* ; Höbler, A.L.* ; Klimek, P.* ; Leutner, M.* ; Yamamoto, M.* ; Suzuki, N.* ; Stemmer, K. ; Zeyda, M.* ; Steinacher, D.* ; Nics, L.* ; Müller, A.M.S.* ; Helbich, T.H.* ; Moriggl, R.* ; Kautzky-Willer, A.* ; Windberger, U.* ; Prager, G.* ; Fürnsinn, C.*

A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice.

Sci. Adv. 11:eadt7366 (2025)
Verlagsversion DOI PMC
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Blood glucose is lower in mountain dwellers living under low partial oxygen pressure. We show that obese mice maintained under hypoxia exhibit a delayed but distinct decrease in blood glucose with improved insulin sensitivity, which is independent of changes in body weight. This effect of hypoxia is mediated by erythropoiesis and is a direct result of the rising hematocrit, which could be due to erythrocytes acting as carriers of glucose units in the blood. Glucose lowering by the red cell mass is evidenced by a prompt decrease in glycemia in mice receiving a blood transfusion. Furthermore, life under hypoxia as well as treatment with erythropoietin reduce glycemia also in mice expressing the erythropoietin receptor exclusively in hematopoietic cells, which contrasts with previous assumptions attributing metabolic actions of erythropoietin to direct action on nonhematopoietic tissues. Our results provide a rationale for associations between hematocrit and blood glucose in humans under anti-anemic therapy, polycythemia, smoking, and high-altitude exposure.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Recombinant-human-erythropoietin; Inverse Association; Insulin Sensitivity; High-altitude; Homeostasis; Testosterone; Performance; Expression; Obesity; Diet
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 11, Heft: 16, Seiten: , Artikelnummer: eadt7366 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-221
Förderungen Skolkovo (Moskow School of Management, Russia)
Austrian Science Fund (FWF)
DOI 10.1126/sciadv.adt7366
WOS ID 001468720700017
Scopus ID 105003215966
PubMed ID 40238885
Erfassungsdatum 2025-05-10
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