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Tschuck, J. ; Skafar, V.* ; Friedmann Angeli, J.P.* ; Hadian, K.

The metabolic code of ferroptosis: Nutritional regulators of cell death.

Trends Biochem. Sci. 50, 663-676 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finely tuned by metabolic pathways, transcription factors, and nuclear receptors that control lipid peroxidation levels. Significantly, nutrients such as vitamins and trace elements play a pivotal role in this regulation, directly linking diet and nutrients to cellular fate. This review conveys the latest insights into the metabolic components that influence ferroptosis. We highlight how metabolic and transcriptional regulators and key nutrients, micronutrients, and metabolites orchestrate this process. Charting these interactions will be essential for developing new avenues for therapeutic interventions targeting ferroptosis in various diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Ferroptosis ; Lipid Peroxidation ; Lipids ; Metabolites ; Nutrients ; Vitamins; Human-diploid Fibroblasts; Lipid-peroxidation; Mechanisms; Degradation; Activation; Resistance; Depletion; Cystine; Gsh
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0376-5067
e-ISSN 0968-0004
Zeitschrift Trends in Biochemical Sciences : TIBS
Quellenangaben Band: 50, Heft: 8, Seiten: 663-676 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Signaling and Translation (SAT)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-509800-003
DOI 10.1016/j.tibs.2025.04.007
WOS ID 001587089400004
Scopus ID 105006612865
PubMed ID 40441931
Erfassungsdatum 2025-06-05
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