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Histone modifications in development.
Development 152:dev204384 (2025)
In eukaryotic cells, the genetic material is organized into chromatin, which consists mainly of DNA, histones and chromatin-associated proteins. An important regulator of chromatin structure and function are histone post-translational modifications, which can shape gene expression patterns and control the epigenetic landscape. Here, we summarize the role of some key histone modifications in animal development, with a focus on the two best-studied types of histone modifications: lysine methylation and acylations, specifically, acetylation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Acetylation ; Histone Modification ; Methylation ; Mutation; Molecular-mechanisms; Chromatin-structure; Gene-expression; Lateral Surface; Acetylation; H3; Phosphorylation; Transcription; Nucleosome; Differentiation
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Zeitschrift
Development / Company of Biologists
Quellenangaben
Band: 152,
Heft: 12,
Artikelnummer: dev204384
Verlag
Company of Biologists
Verlagsort
Bidder Building, Station Rd, Histon, Cambridge Cb24 9lf, England
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Functional Epigenetics (IFE)
Förderungen
Helmholtz-Gemeinschaft