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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons.
Development 136, 253-262 (2009)
Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active in GABAergic neurogenesis and show their correlation with the expression of the transcription factor Gata2. Using tissue-specific inactivation and ectopic expression, we show that Gata2 regulates GABAergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and instead switch to a glutamatergic phenotype. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
GABA; Interneuron; Midbrain; Neurotransmitter; Mouse; Neurogenesis; Ventral tegmental area (VTA); Serotonin; Dorsal raphe; Rhombomere 1; mouse superior colliculus; inner-ear development; periaqueductal gray; cell fate; serotonergic neurons; spinal-cord; expression; differentiation; hindbrain; behavior
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Zeitschrift
Development / Company of Biologists
Quellenangaben
Band: 136,
Heft: 2,
Seiten: 253-262
Verlag
Company of Biologists
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Developmental Genetics (IDG)