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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Simulation of 125I induced DNA strand breaks in a CAP-DNA complex.
Radiat. Prot. Dosim. 99, 109-112 (2002)
The E. coli catabolite gene activator protein (CAP)-DNA complex with I-125 located at the position of the H5 atom of the cytosine near the centre was incorporated into the PARTRAC track structure code. DNA strand breaks due to irradiation were calculated by track structure and radical attack simulations strand breaks due to neutralisation of the highly charged Te-125 ion were derived from a semi-empirical distribution. According to the calculations, the neutralisation effect dominates the strand breakage frequency at 2 bases away front the I-125 decay site on both strands. The first breakage distribution counted from a P-32 labelled end on the strand with I-125 agreed well with experimental data. but on the opposite strand. the calculated distribution is more concentrated around the decay site and its yield is about 20% larger than the measured data.
Impact Factor
Scopus SNIP
0.768
0.000
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
MONTE-CARLO SIMULATION; SYNTHETIC OLIGODEOXYNUCLEOTIDE; LIQUID WATER; DECAY; IRRADIATION; MODELS
Sprache
englisch
Veröffentlichungsjahr
2002
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 99,
Seiten: 109-112
Verlag
Oxford University Press
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-501100-004
Erfassungsdatum
2002-10-16