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Li, W. ; Friedland, W. ; Jacob, P. ; Paretzke, H.G. ; Panyutin, I.* ; Neumann, R.D.*

Simulation of 125I induced DNA strand breaks in a CAP-DNA complex.

Radiat. Prot. Dosim. 99, 109-112 (2002)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The E. coli catabolite gene activator protein (CAP)-DNA complex with I-125 located at the position of the H5 atom of the cytosine near the centre was incorporated into the PARTRAC track structure code. DNA strand breaks due to irradiation were calculated by track structure and radical attack simulations strand breaks due to neutralisation of the highly charged Te-125 ion were derived from a semi-empirical distribution. According to the calculations, the neutralisation effect dominates the strand breakage frequency at 2 bases away front the I-125 decay site on both strands. The first breakage distribution counted from a P-32 labelled end on the strand with I-125 agreed well with experimental data. but on the opposite strand. the calculated distribution is more concentrated around the decay site and its yield is about 20% larger than the measured data.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter MONTE-CARLO SIMULATION; SYNTHETIC OLIGODEOXYNUCLEOTIDE; LIQUID WATER; DECAY; IRRADIATION; MODELS
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Zeitschrift Radiation Protection Dosimetry
Quellenangaben Band: 99, Heft: , Seiten: 109-112 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)