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Open Access Green as soon as Postprint is submitted to ZB.
Random ENU Mutagenesis.
Methods Mol. Biol. 209, 249-266 (2003)
Mouse models play an important role in the elucidation of molecular pathways underlying human disease. Mutations in mouse can be generated by a variety of techniques including those using inducing agents such ionizing radiation or chemicals and those that involve genetic manipulations such as transgenic insertions or knockouts. Random mutagenesis by ionizing radiation or chemical agents has a long tradition in classical genetics and has allowed the generation of a large number of mutant phenotypes. Ionizing radiation causes breaks in the chromosome, leading to deletions, translocations, and other gross chromosomal rearrangements. Chemical mutagens, which have been shown to produce a large number of mutations, are characterised by a differential spermatogenic response.
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Publication type
Article: Journal article
Document type
Scientific Article
Editors
Hofker, M.H.* ; Deursen, J.*
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Conference Title
Transgenic Mouse : Methods and Protocols
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 209,
Pages: 249-266
Publisher
Springer
Publishing Place
Berlin [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)