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Lindgren, C.M.* ; Heid, I.M. ; Randall, J.C.* ; Lamina, C. ; Steinthorsdottir, V.* ; Qi, L.* ; Speliotes, E.K.* ; Thorleifsson, G.* ; Willer, C.J.* ; Herrera, B.M.* ; Jackson, A.U.* ; Lim, N.* ; Scheet, P.* ; Soranzo, N.* ; Amin, N.* ; Aulchenko, Y.S.* ; Chambers, J.C.* ; Drong, A.* ; Luan, J.A.* ; Lyon, H.N.* ; Rivadeneira, F.* ; Sanna, S.* ; Timpson, N.J.* ; Zillikens, M.C.* ; Zhao, J.H.* ; Almgren, P.* ; Bandinelli, S.* ; Bennett, A.J.* ; Bergman, R.N.* ; Bonnycastle, L.L.* ; Bumpstead, S.J.* ; Chanock, S.J.* ; Cherkas, L.* ; Chines, P.* ; Coin, L.* ; Cooper, C.* ; Crawford, G.* ; Döring, A.* ; Dominiczak, A.* ; Doney, A.S.* ; Ebrahim, S.* ; Elliott, P.* ; Erdos, M.R.* ; Estrada, K.* ; Ferrucci, L.* ; Fischer, G. ; Forouhi, N.G.* ; Gieger, C. ; Grallert, H. ; Groves, C.J.* ; Grundy, S.* ; Guiducci, C.* ; Hadley, D.* ; Hamsten, A.* ; Havulinna, A.S.* ; Hofman, A.* ; Holle, R. ; Holloway, J.W.* ; Illig, T. ; Isomaa, B.* ; Jacobs, L.C.* ; Jameson, K.* ; Jousilahti, P.* ; Karpe, F.* ; Kuusisto, J.* ; Laitinen, J.* ; Lathrop, G.M.* ; Lawlor, D.A.* ; Mangino, M.* ; McArdle, W.L.* ; Meitinger, T. ; Morken, M.A.* ; Morris, A.P.* ; Munroe, P.* ; Narisu, N.* ; Nordstrom, A.* ; Nordstrom, P.* ; Oostra, B.A.* ; Palmer, C.N.A.* ; Payne, F.* ; Peden, J.F.* ; Prokopenko, I.* ; Renström, F.* ; Ruokonen, A.* ; Salomaa, V.* ; Sandhu, M.S.* ; Scott, L.J.* ; Scuteri, A.* ; Silander, K.* ; Song, K.J.* ; Yuan, X.* ; Stringham, H.M.* ; Swift, A.J.* ; Tuomi, T.* ; Uda, M.* ; Vollenweider, P.* ; Waeber, G.* ; Wallace, C.* ; Walters, G.B.* ; Weedon, M.N.* ; Witteman, J.C.M.* ; Zhang, C.L.* ; Zhang, W.H.* ; Caulfield, M.J.* ; Collins, F.S.* ; Smith, G.D.* ; Day, I.N.M.* ; Franks, P.W.* ; Hattersley, A.T.* ; Hu, F.B.* ; Jarvelin, M.R.* ; Kong, A.* ; Kooner, J.S.* ; Laakso, M.* ; Lakatta, E.* ; Mooser, V.* ; Morris, A.D.* ; Peltonen, L.* ; Samani, N.J.* ; Spector, T.D.* ; Strachan, D.P.* ; Tanaka, T.* ; Tuomilehto, J.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; Wareham, N.J.* ; Watkins, H.* ; Waterworth, D.M.* ; Boehnke, M.* ; Deloukas, P.* ; Groop, L.* ; Hunter, D.J.* ; Thorsteinsdottir, U.* ; Schlessinger, D.* ; Wichmann, H.-E. ; Frayling, T.M.* ; Abecasis, G.R.* ; Hirschhorn, J.N.* ; Loos, R.J.F.* ; Stefansson, K.* ; Mohlke, K.L.* ; Barroso, I.S.* ; McCarthy, M.I.*

Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution.

PLoS Genet. 5:e1000508 (2009)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords waist circumference; adult obesity; fto gene; environmental-conditions; insulin-resistance; sequence variants; common variants; expression; imputation; height; FTO GENE; WAIST CIRCUMFERENCE; ADULT OBESITY; ENVIRONMENTAL-CONDITIONS; INSULIN-RESISTANCE; SEQUENCE VARIANTS; COMMON VARIANTS; EXPRESSION; IMPUTATION; HEIGHT
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Journal PLoS Genetics
Quellenangaben Volume: 5, Issue: 6, Pages: , Article Number: e1000508 Supplement: ,
Publisher Public Library of Science (PLoS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Health Economics and Health Care Management (IGM)