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Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.

Bioessays 35, 242-252 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
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Publication type Article: Journal article
Document type Review
Keywords Fate Commitment ; Lineage ; Neural Stem Cell ; Neurogenesis; Neural Stem-cells ; Fibroblast Growth Factor-2 ; Nuclear Receptor Tlx ; Bone Morphogenetic Proteins ; In-vivo ; Subventricular Zone ; Self-renewal ; Hippocampal Neurogenesis ; Lineage Plasticity ; Progenitor Cells
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0265-9247
e-ISSN 1521-1878
Journal BioEssays
Quellenangaben Volume: 35, Issue: 3, Pages: 242-252 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
PubMed ID 23335359
Scopus ID 84873569754
Erfassungsdatum 2013-03-15