Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
Bioessays 35, 242-252 (2013)
In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Fate Commitment ; Lineage ; Neural Stem Cell ; Neurogenesis; Neural Stem-cells ; Fibroblast Growth Factor-2 ; Nuclear Receptor Tlx ; Bone Morphogenetic Proteins ; In-vivo ; Subventricular Zone ; Self-renewal ; Hippocampal Neurogenesis ; Lineage Plasticity ; Progenitor Cells
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Journal
BioEssays
Quellenangaben
Volume: 35,
Issue: 3,
Pages: 242-252
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)