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Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
Bioessays 35, 242-252 (2013)
In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
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Publication type
Article: Journal article
Document type
Review
Keywords
Fate Commitment ; Lineage ; Neural Stem Cell ; Neurogenesis; Neural Stem-cells ; Fibroblast Growth Factor-2 ; Nuclear Receptor Tlx ; Bone Morphogenetic Proteins ; In-vivo ; Subventricular Zone ; Self-renewal ; Hippocampal Neurogenesis ; Lineage Plasticity ; Progenitor Cells
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Journal
BioEssays
Quellenangaben
Volume: 35,
Issue: 3,
Pages: 242-252
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500800-001
PubMed ID
23335359
WOS ID
WOS:000314914400014
Scopus ID
84873569754
Erfassungsdatum
2013-03-15