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Chang, X.* ; Xu, T. ; Li, Y.* ; Wang, K.*

Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of 'date' and 'party' hubs.

Sci. Rep. 3:1691 (2013)
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The protein-protein interaction (PPI) networks are dynamically organized as modules, and are typically described by hub dichotomy: 'party' hubs act as intramodule hubs and are coexpressed with their partners, yet 'date' hubs act as coordinators among modules and are incoherently expressed with their partners. However, there remains skepticism about the existence of hub dichotomy. Since different algorithms and data sets were used in previous studies to test the model of hub classification, the conclusions may be largely influenced by the potential inherent biases. In this study, we evaluated two data sets of yeast interactome, and systematically investigated the behavior of hubs from multiple perspectives including co-expression patterns, topological roles and functional classifications. Our results revealed consistency between the two data sets, confirming the presence of hub dichotomy. Furthermore, we analyzed a human interactome data set, and demonstrated that the modular architecture of the PPI networks was more complicated than hub dichotomy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Saccharomyces-cerevisiae ; Ribosome Biogenesis ; Community Structure ; Yeast ; Identification ; Cells
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 3, Issue: , Pages: , Article Number: 1691 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Epidemiology (AME)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504200-003
PubMed ID 23603706
DOI 10.1038/srep01691
WOS ID WOS:000317814700003
Scopus ID 84877730113
Erfassungsdatum 2013-05-23
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