Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels.
Histochem. Cell Biol. 140, 93-104 (2013)
Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and quantitative distribution maps of small pharmaceutical-active molecules and their metabolites in tissue sections in situ. The simplicity, high sensitivity and ability to provide comprehensive spatial distribution maps of different classes of biomolecules make MSI a valuable tool to complement histopathology for diagnostics and biomarker discovery. In this review, qualitative and quantitative MSI of drugs and metabolites in tissue at therapeutic levels are discussed and the impact of this technique in drug discovery and clinical research is highlighted.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Mass Spectrometry Imaging; Quantitation; Drug; Metabolite; In Situ; High Resolution; Direct Molecular Analysis ; Rat-brain Tissue ; Maldi-ms ; High-resolution ; Ion-trap ; Matrix ; Sections ; Localization ; Normalization ; Distributions
ISSN (print) / ISBN
0948-6143
e-ISSN
1432-119X
Journal
Histochemistry and Cell Biology
Quellenangaben
Volume: 140,
Issue: 2,
Pages: 93-104
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed