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Functional ribosome biogenesis is a prerequisite for p53 destabilization: Impact of chemotherapy on nucleolar functions and RNA metabolism.
Biol. Chem. 394, 1133-1143 (2013)
Publ. Version/Full Text Volltext
DOI
PMC
The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.
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Publication type
Article: Journal article
Document type
Review
Keywords
Chemotherapy ; Kinase Inhibitor ; Ribosome Biogenesis ; Rrna Processing ; Tumor Suppressor P53; Chronic Lymphocytic-leukemia ; Polymerase-i-transcription ; Cyclin-dependent Kinases ; Human Cancer-cells ; Wild-type P53 ; Protein-synthesis ; Dna-damage ; Cytoplasmic Maturation ; Nuclear Accumulation ; Carcinoma Cells
ISSN (print) / ISBN
1431-6730
e-ISSN
1437-4315
Journal
Biological Chemistry
Quellenangaben
Volume: 394,
Issue: 9,
Pages: 1133-1143
Publisher
de Gruyter
Non-patent literature
Publications
Reviewing status
Peer reviewed