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Vinceti, M.* ; Mandrioli, J.* ; Borella, P.* ; Michalke, B. ; Tsatsakis, A.* ; Finkelstein, Y.*

Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies.

Toxicol. Lett. 230, 295-303 (2014)

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	Open Access Green

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Selenium is a metalloid of considerable interest in the human from both a toxicological and a nutritional perspective, with a very narrow safe range of intake. Acute selenium intoxication is followed by adverse effects on the nervous system with special clinical relevance, while the neurotoxicity of long-term overexposure is less characterized and recognized. We aimed to address this issue from a public health perspective, focusing on both laboratory studies and the few epidemiologic human studies available, with emphasis on their methodological strengths and limitations. The frequently overlooked differences in toxicity and biological activity of selenium compounds are also outlined. In addition to lethargy, dizziness, motor weakness and paresthesias, an excess risk of amyotrophic lateral sclerosis is the effect on the nervous system which has been more consistently associated with chronic low-level selenium overexposure, particularly to its inorganic compounds. Additional research efforts are needed to better elucidate the neurotoxic effects exerted by selenium overexposure.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Selenium ; Neurotoxicity Syndromes ; Nervous System Diseases ; Amyotrophic Lateral Sclerosis ; Epidemiologic Studies ; Risk Assessment; Amyotrophic-lateral-sclerosis; Motor-neuron Disease; Prostaglandin-d Synthase; Long-term Exposure; Sodium Selenite; Dietary Selenium; Inorganic Selenium; Selenoprotein P; Drinking-water; Environmental Selenium

ISSN (print) / ISBN 0378-4274

e-ISSN 1879-3169

Journal Toxicology Letters

Quellenangaben Volume: 230, Issue: 2, Pages: 295-303

Publisher Elsevier

Publishing Place Amsterdam

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Analytical BioGeoChemistry (BGC)