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Blind spectral unmixing to identify molecular signatures of absorbers in multispectral optoacoustic tomography.
Proc. SPIE 7899:78993D (2011)
Publ. Version/Full Text
DOI
Multispectral optoacoustic (photoacoustic) tomography (MSOT) exploits the high resolutions provided by ultrasound imaging technology in combination with the more biologically relevant optical absorption contrast. Traces of molecules with different spectral absorption profiles, such as blood (oxy- and de-oxygenated) and biomarkers can be recovered using multiple wavelengths excitation and a set of methods described in this work. Three unmixing methods are examined for their performance in decomposing images into components in order to locate fluorescent contrast agents in deep tissue in mice. Following earlier works we find Independent Component Analysis (ICA), which relies on the strong criterion of statistical independence of components, as the most promising approach, being able to clearly identify concentrations that other approaches fail to see. The results are verified by cryosectioning and fluorescence imaging.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Photons Plus Ultrasound: Imaging and Sensing 2011
Conference Date
January 22, 2011
Conference Location
San Francisco, California, USA
Journal
Proceedings of SPIE
Quellenangaben
Volume: 7899,
Article Number: 78993D
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)